Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 HIV type 1 Gag as a target for antiviral therapy.

Literature DB >> 21848364

HIV type 1 Gag as a target for antiviral therapy.

Abstract

The Gag proteins of HIV-1 are central players in virus particle assembly, release, and maturation, and also function in the establishment of a productive infection. Despite their importance throughout the replication cycle, there are currently no approved antiretroviral therapies that target the Gag precursor protein or any of the mature Gag proteins. Recent progress in understanding the structural and cell biology of HIV-1 Gag function has revealed a number of potential Gag-related targets for possible therapeutic intervention. In this review, we summarize our current understanding of HIV-1 Gag and suggest some approaches for the development of novel antiretroviral agents that target Gag.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21848364 PMCID： PMC3251841 DOI： 10.1089/AID.2011.0230

Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205

273 in total

1. Image reconstructions of helical assemblies of the HIV-1 CA protein.

Authors: S Li; C P Hill; W I Sundquist; J T Finch
Journal: Nature Date: 2000-09-21 Impact factor: 49.962

2. Entropic switch regulates myristate exposure in the HIV-1 matrix protein.

Authors: Chun Tang; Erin Loeliger; Paz Luncsford; Isaac Kinde; Dorothy Beckett; Michael F Summers
Journal: Proc Natl Acad Sci U S A Date: 2003-12-29 Impact factor: 11.205

3. Hydrazone- and hydrazide-containing N-substituted glycines as peptoid surrogates for expedited library synthesis: application to the preparation of Tsg101-directed HIV-1 budding antagonists.

Authors: Fa Liu; Andrew G Stephen; Catherine S Adamson; Karine Gousset; M Javad Aman; Eric O Freed; Robert J Fisher; Terrence R Burke
Journal: Org Lett Date: 2006-10-26 Impact factor: 6.005

4. Analysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids.

Authors: Ayna Alfadhli; Amelia Still; Eric Barklis
Journal: J Virol Date: 2009-09-23 Impact factor: 5.103

5. Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.

Authors: Charles R Langelier; Virginie Sandrin; Debra M Eckert; Devin E Christensen; Viswanathan Chandrasekaran; Steven L Alam; Christopher Aiken; John C Olsen; Alak Kanti Kar; Joseph G Sodroski; Wesley I Sundquist
Journal: J Virol Date: 2008-09-17 Impact factor: 5.103

6. Mutations of basic amino acids of NCp7 of human immunodeficiency virus type 1 affect RNA binding in vitro.

Authors: E Schmalzbauer; B Strack; J Dannull; S Guehmann; K Moelling
Journal: J Virol Date: 1996-02 Impact factor: 5.103

7. Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: implications for retroviral assembly mechanisms.

Authors: M Yeager; E M Wilson-Kubalek; S G Weiner; P O Brown; A Rein
Journal: Proc Natl Acad Sci U S A Date: 1998-06-23 Impact factor: 11.205

8. Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation.

Authors: Jing Zhou; Xiong Yuan; David Dismuke; Brett M Forshey; Christopher Lundquist; Kuo-Hsiung Lee; Christopher Aiken; Chin Ho Chen
Journal: J Virol Date: 2004-01 Impact factor: 5.103

9. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes.

Authors: Kosuke Miyauchi; Yuri Kim; Olga Latinovic; Vladimir Morozov; Gregory B Melikyan
Journal: Cell Date: 2009-05-01 Impact factor: 41.582

10. Structure of full-length HIV-1 CA: a model for the mature capsid lattice.

Authors: Barbie K Ganser-Pornillos; Anchi Cheng; Mark Yeager
Journal: Cell Date: 2007-10-05 Impact factor: 41.582

41 in total

1. Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy.

Authors: Tanmay A M Bharat; Norman E Davey; Pavel Ulbrich; James D Riches; Alex de Marco; Michaela Rumlova; Carsten Sachse; Tomas Ruml; John A G Briggs
Journal: Nature Date: 2012-07-19 Impact factor: 49.962

2. Magic angle spinning NMR reveals sequence-dependent structural plasticity, dynamics, and the spacer peptide 1 conformation in HIV-1 capsid protein assemblies.

Authors: Yun Han; Guangjin Hou; Christopher L Suiter; Jinwoo Ahn; In-Ja L Byeon; Andrew S Lipton; Sarah Burton; Ivan Hung; Peter L Gor'kov; Zhehong Gan; William Brey; David Rice; Angela M Gronenborn; Tatyana Polenova
Journal: J Am Chem Soc Date: 2013-11-13 Impact factor: 15.419

3. Association equilibrium of the HIV-1 capsid protein in a crowded medium reveals that hexamerization during capsid assembly requires a functional C-domain dimerization interface.

Authors: Rebeca Bocanegra; Carlos Alfonso; Alicia Rodríguez-Huete; Miguel Ángel Fuertes; Mercedes Jiménez; Germán Rivas; Mauricio G Mateu
Journal: Biophys J Date: 2013-02-19 Impact factor: 4.033

4. Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly.

Authors: Tanmay A M Bharat; Luis R Castillo Menendez; Wim J H Hagen; Vanda Lux; Sebastien Igonet; Martin Schorb; Florian K M Schur; Hans-Georg Kräusslich; John A G Briggs
Journal: Proc Natl Acad Sci U S A Date: 2014-05-19 Impact factor: 11.205

5. Investigation of the structure and dynamics of the capsid-spacer peptide 1-nucleocapsid fragment of the HIV-1 gag polyprotein by solution NMR spectroscopy.

Authors: Lalit Deshmukh; Rodolfo Ghirlando; G Marius Clore
Journal: Angew Chem Int Ed Engl Date: 2013-12-11 Impact factor: 15.336

6. Allosteric Regulation of HIV-1 Capsid Structure for Gag Assembly, Virion Production, and Viral Infectivity by a Disordered Interdomain Linker.

Authors: Takaaki Koma; Osamu Kotani; Kei Miyakawa; Akihide Ryo; Masaru Yokoyama; Naoya Doi; Akio Adachi; Hironori Sato; Masako Nomaguchi
Journal: J Virol Date: 2019-08-13 Impact factor: 5.103

7. Effects of an HIV-1 maturation inhibitor on the structure and dynamics of CA-SP1 junction helices in virus-like particles.

Authors: Sebanti Gupta; John M Louis; Robert Tycko
Journal: Proc Natl Acad Sci U S A Date: 2020-04-27 Impact factor: 11.205