Literature DB >> 20948534

Overcoming obstacles to developing new analgesics.

Clifford J Woolf1.   

Abstract

Despite substantial investment by the pharmaceutical industry over several decades, there has been little progress in developing new, efficacious and safe analgesics. As a result, many large pharmaceutical companies are leaving the area of pain medication. Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging.

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Year:  2010        PMID： 20948534     DOI： 10.1038/nm.2230

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  58 in total

Review 1.  Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations.

Authors:  Robert H Dworkin; Dennis C Turk; Sarah Peirce-Sandner; Ralf Baron; Nicholas Bellamy; Laurie B Burke; Amy Chappell; Kevin Chartier; Charles S Cleeland; Ann Costello; Penney Cowan; Rozalina Dimitrova; Susan Ellenberg; John T Farrar; Jacqueline A French; Ian Gilron; Sharon Hertz; Alejandro R Jadad; Gary W Jay; Jarkko Kalliomäki; Nathaniel P Katz; Robert D Kerns; Donald C Manning; Michael P McDermott; Patrick J McGrath; Arvind Narayana; Linda Porter; Steve Quessy; Bob A Rappaport; Christine Rauschkolb; Bryce B Reeve; Thomas Rhodes; Cristina Sampaio; David M Simpson; Joseph W Stauffer; Gerold Stucki; Jeffrey Tobias; Richard E White; James Witter
Journal:  Pain       Date:  2010-03-06       Impact factor: 6.961

2.  A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

Authors:  G Gregory Neely; Keiji Kuba; Anthony Cammarato; Kazuya Isobe; Sabine Amann; Liyong Zhang; Mitsushige Murata; Lisa Elmén; Vaijayanti Gupta; Suchir Arora; Rinku Sarangi; Debasis Dan; Susumu Fujisawa; Takako Usami; Cui-ping Xia; Alex C Keene; Nakissa N Alayari; Hiroyuki Yamakawa; Ulrich Elling; Christian Berger; Maria Novatchkova; Rubina Koglgruber; Keiichi Fukuda; Hiroshi Nishina; Mitsuaki Isobe; J Andrew Pospisilik; Yumiko Imai; Arne Pfeufer; Andrew A Hicks; Peter P Pramstaller; Sai Subramaniam; Akinori Kimura; Karen Ocorr; Rolf Bodmer; Josef M Penninger
Journal:  Cell       Date:  2010-04-02       Impact factor: 41.582

Review 3.  Neuronal plasticity: increasing the gain in pain.

Authors:  C J Woolf; M W Salter
Journal:  Science       Date:  2000-06-09       Impact factor: 47.728

Review 4.  Recommendations for the pharmacological management of neuropathic pain: an overview and literature update.

Authors:  Robert H Dworkin; Alec B O'Connor; Joseph Audette; Ralf Baron; Geoffrey K Gourlay; Maija L Haanpää; Joel L Kent; Elliot J Krane; Alyssa A Lebel; Robert M Levy; Sean C Mackey; John Mayer; Christine Miaskowski; Srinivasa N Raja; Andrew S C Rice; Kenneth E Schmader; Brett Stacey; Steven Stanos; Rolf-Detlef Treede; Dennis C Turk; Gary A Walco; Christopher D Wells
Journal:  Mayo Clin Proc       Date:  2010-03       Impact factor: 7.616

Review 5.  An evidence-based algorithm for the treatment of neuropathic pain.

Authors:  Nanna B Finnerup; Marit Otto; Troels S Jensen; Søren H Sindrup
Journal:  MedGenMed       Date:  2007-05-15

Review 6.  Neuropathic pain: a maladaptive response of the nervous system to damage.

Authors:  Michael Costigan; Joachim Scholz; Clifford J Woolf
Journal:  Annu Rev Neurosci       Date:  2009       Impact factor: 12.449

Review 7.  Assessment and management of acute pain in adult medical inpatients: a systematic review.

Authors:  Mark Helfand; Michele Freeman
Journal:  Pain Med       Date:  2009-10       Impact factor: 3.750

Review 8.  Pharmacology and treatment of neuropathic pains.

Authors:  Troels S Jensen; Caspar S Madsen; Nanna B Finnerup
Journal:  Curr Opin Neurol       Date:  2009-10       Impact factor: 5.710

9.  A novel tool for the assessment of pain: validation in low back pain.

Authors:  Joachim Scholz; Richard J Mannion; Daniela E Hord; Robert S Griffin; Bhupendra Rawal; Hui Zheng; Daniel Scoffings; Amanda Phillips; Jianli Guo; Rodney J C Laing; Salahadin Abdi; Isabelle Decosterd; Clifford J Woolf
Journal:  PLoS Med       Date:  2009-04-07       Impact factor: 11.069

10.  Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuli.

Authors:  Lino Becerra; Will Harris; Margaret Grant; Edward George; David Boas; David Borsook
Journal:  PLoS One       Date:  2009-11-24       Impact factor: 3.240
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  75 in total

1.  Analgesia: lipid linked to improved opiate therapy.

Authors:  Samia Burridge
Journal:  Nat Rev Drug Discov       Date:  2011-01       Impact factor: 84.694

2.  Etoricoxib improves osteoarthritis pain relief, joint function, and quality of life in the extreme elderly.

Authors:  Wen-Nan Huang; Tim K Tso
Journal:  Bosn J Basic Med Sci       Date:  2018-02-20       Impact factor: 3.363

3.  A new hypertonic saline assay for analgesic screening in mice: effects of animal strain, sex, and diurnal phase.

Authors:  Yahya I Asiri; Desmond H Fung; Timothy Fung; Alasdair M Barr; Ernest Puil; Stephan K W Schwarz; Bernard A MacLeod
Journal:  Can J Anaesth       Date:  2021-02-18       Impact factor: 5.063

Review 4.  Breaking barriers to novel analgesic drug development.

Authors:  Ajay S Yekkirala; David P Roberson; Bruce P Bean; Clifford J Woolf
Journal:  Nat Rev Drug Discov       Date:  2017-06-09       Impact factor: 84.694

Review 5.  Monoacylglycerol lipase - a target for drug development?

Authors:  C J Fowler
Journal:  Br J Pharmacol       Date:  2012-07       Impact factor: 8.739

Review 6.  Microglial Modulation as a Target for Chronic Pain: From the Bench to the Bedside and Back.

Authors:  Elena S Haight; Thomas E Forman; Stephanie A Cordonnier; Michelle L James; Vivianne L Tawfik
Journal:  Anesth Analg       Date:  2019-04       Impact factor: 5.108

7.  [Pain measurement in animal models].

Authors:  M Busch-Dienstfertig; C Stein
Journal:  Z Rheumatol       Date:  2013-03       Impact factor: 1.372

8.  Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.

Authors:  Jia Yu Peppermint Lee; Natalie J Saez; Ben Cristofori-Armstrong; Raveendra Anangi; Glenn F King; Maree T Smith; Lachlan D Rash
Journal:  Br J Pharmacol       Date:  2018-01-03       Impact factor: 8.739

9.  Black mamba venom peptides target acid-sensing ion channels to abolish pain.

Authors:  Sylvie Diochot; Anne Baron; Miguel Salinas; Dominique Douguet; Sabine Scarzello; Anne-Sophie Dabert-Gay; Delphine Debayle; Valérie Friend; Abdelkrim Alloui; Michel Lazdunski; Eric Lingueglia
Journal:  Nature       Date:  2012-10-03       Impact factor: 49.962

Review 10.  Preclinical Pain Research: Can We Do Better?

Authors:  J David Clark
Journal:  Anesthesiology       Date:  2016-11       Impact factor: 7.892
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