Literature DB >> 20945888

Computational design of a self-assembling β-peptide oligomer.

Ivan V Korendovych1, Yong Ho Kim, Andrew H Ryan, James D Lear, William F Degrado, Scott J Shandler.   

Abstract

The first computationally designed self-assembling oligomer consisting of exclusively β-amino acids (βAAs) is presented. The packing of a β-3(14) helix into coiled-coils of varying stoichiometries as a function of amino acid sequence is examined. β-Peptides with hVal repeating every third residue in the sequence appeared to have a strong propensity to pack into hexameric bundles. The designed sequence was synthesized and characterized with CD spectroscopy, NMR, and analytical ultracentrifugation, suggesting that the peptide adopts a well-folded hexameric structure.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20945888      PMCID： PMC3807245          DOI： 10.1021/ol102092r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  33 in total

Review 1.  Rotamer libraries in the 21st century.

Authors:  Roland L Dunbrack
Journal:  Curr Opin Struct Biol       Date:  2002-08       Impact factor: 6.809

2.  Circular dichroism spectra of beta-peptides: sensitivity to molecular structure and effects of motional averaging.

Authors:  Xavier Daura; Dirk Bakowies; Dieter Seebach; Jörg Fleischhauer; Wilfred F van Gunsteren; Peter Krüger
Journal:  Eur Biophys J       Date:  2003-09-16       Impact factor: 1.733

3.  Helix bundle quaternary structure from alpha/beta-peptide foldamers.

Authors:  W Seth Horne; Joshua L Price; James L Keck; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2007-03-16       Impact factor: 15.419

4.  Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.

Authors:  W Seth Horne; Melissa D Boersma; Matthew A Windsor; Samuel H Gellman
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

5.  Discrete heterogeneous quaternary structure formed by alpha/beta-peptide foldamers and alpha-peptides.

Authors:  Joshua L Price; W Seth Horne; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2007-04-28       Impact factor: 15.419

6.  Do-it-yourself enzymes.

Authors:  Vikas Nanda
Journal:  Nat Chem Biol       Date:  2008-05       Impact factor: 15.040

7.  Development of a rotamer library for use in beta-peptide foldamer computational design.

Authors:  Scott J Shandler; Maxim V Shapovalov; Roland L Dunbrack; William F DeGrado
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

8.  Backbone-dependent rotamer library for proteins. Application to side-chain prediction.

Authors:  R L Dunbrack; M Karplus
Journal:  J Mol Biol       Date:  1993-03-20       Impact factor: 5.469

9.  Beta-peptidic peptidomimetics.

Authors:  Dieter Seebach; James Gardiner
Journal:  Acc Chem Res       Date:  2008-06-26       Impact factor: 22.384

10.  An alpha/beta-peptide helix bundle with a pure beta3-amino acid core and a distinctive quaternary structure.

Authors:  Michael W Giuliano; W Seth Horne; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2009-07-29       Impact factor: 15.419
View more
  14 in total

1.  Computational biology: A recipe for ligand-binding proteins.

Authors:  Giovanna Ghirlanda
Journal:  Nature       Date:  2013-09-04       Impact factor: 49.962

2.  2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel.

Authors:  Ayanjeet Ghosh; Jun Wang; Yurii S Moroz; Ivan V Korendovych; Martin Zanni; William F DeGrado; Feng Gai; Robin M Hochstrasser
Journal:  J Chem Phys       Date:  2014-06-21       Impact factor: 3.488

3.  Instructed-Assembly of Small Peptides Inhibits Drug-Resistant Prostate Cancer Cells.

Authors:  Zhaoqianqi Feng; Huaimin Wang; Meihui Yi; Chieh-Yun Lo; Ashanti Sallee; Jer-Tsong Hsieh; Bing Xu
Journal:  Pept Sci (Hoboken)       Date:  2019-06-12

Review 4.  Catalytic peptide assemblies.

Authors:  O Zozulia; M A Dolan; I V Korendovych
Journal:  Chem Soc Rev       Date:  2018-05-21       Impact factor: 54.564

5.  Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β3-amino acids.

Authors:  Ivan V Korendovych; Scott J Shandler; Geronda L Montalvo; William F DeGrado
Journal:  Org Lett       Date:  2011-06-09       Impact factor: 6.005

Review 6.  Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function.

Authors:  Jeffrey Skolnick; Mu Gao; Ambrish Roy; Bharath Srinivasan; Hongyi Zhou
Journal:  Bioorg Med Chem Lett       Date:  2015-02-03       Impact factor: 2.823

7.  Computational design of a β-peptide that targets transmembrane helices.

Authors:  Scott J Shandler; Ivan V Korendovych; David T Moore; Kathryn B Smith-Dupont; Craig N Streu; Rustem I Litvinov; Paul C Billings; Feng Gai; Joel S Bennett; William F DeGrado
Journal:  J Am Chem Soc       Date:  2011-07-22       Impact factor: 15.419

8.  Functional characterization of a melittin analog containing a non-natural tryptophan analog.

Authors:  Zachary Ridgway; Angela L Picciano; Pallavi M Gosavi; Yurii S Moroz; Christopher E Angevine; Amy E Chavis; Joseph E Reiner; Ivan V Korendovych; Gregory A Caputo
Journal:  Biopolymers       Date:  2015-07       Impact factor: 2.505

9.  Synthesis and Self-Assembly of Bundle-Forming α-Helical Peptide-Dendron Hybrids.

Authors:  Jeannette E Marine; Shuang Song; Xiaoli Liang; Jonathan G Rudick
Journal:  Biomacromolecules       Date:  2015-12-23       Impact factor: 6.988

10.  Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice.

Authors:  Katherine E Olson; Lisa M Kosloski-Bilek; Kristi M Anderson; Breha J Diggs; Barbara E Clark; John M Gledhill; Scott J Shandler; R Lee Mosley; Howard E Gendelman
Journal:  J Neurosci       Date:  2015-12-16       Impact factor: 6.167
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.