Literature DB >> 17500570

Iriomoteolide-1a, a potent cytotoxic 20-membered macrolide from a benthic dinoflagellate amphidinium species.

Masashi Tsuda1, Keiko Oguchi, Rie Iwamoto, Yumiko Okamoto, Jun'ichi Kobayashi, Eri Fukushi, Jun Kawabata, Tomoko Ozawa, Atsunori Masuda, Yoshiaki Kitaya, Kenji Omasa.   

Abstract

A potent cytotoxic 20-membered macrolide, iriomoteolide-1a (1), has been isolated from a benthic dinoflagellate Amphidinium sp. (strain HYA024), and the structure was elucidated on the basis of detailed analyses of 2-D NMR data. The relative and absolute stereochemistries were assigned by the combination of conformational analyses using NMR data and modified Mosher's method of 1.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17500570     DOI: 10.1021/jo070414b

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  11 in total

1.  INTEGRATED APPROACHES TO THE CONFIGURATIONAL ASSIGNMENT OF MARINE NATURAL PRODUCTS.

Authors:  Tadeusz F Molinski; Brandon I Morinaka
Journal:  Tetrahedron       Date:  2012-11-18       Impact factor: 2.457

Review 2.  Survey of marine natural product structure revisions: a synergy of spectroscopy and chemical synthesis.

Authors:  Takashi L Suyama; William H Gerwick; Kerry L McPhail
Journal:  Bioorg Med Chem       Date:  2011-06-12       Impact factor: 3.641

3.  Enantioselective syntheses of the proposed structures of cytotoxic macrolides iriomoteolide-1a and -1b.

Authors:  Arun K Ghosh; Hao Yuan
Journal:  Org Lett       Date:  2010-07-16       Impact factor: 6.005

4.  Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.

Authors:  Arun K Ghosh
Journal:  J Org Chem       Date:  2010-10-11       Impact factor: 4.354

5.  Enantioselective synthesis of the C1-C6 and C7-C23 fragments of the proposed structure of iriomoteolide 1a.

Authors:  Michael T Crimmins; Anne-Marie R Dechert
Journal:  Org Lett       Date:  2012-04-18       Impact factor: 6.005

6.  Stereoselective synthesis of the C(1)-C(12) segment of iriomoteolide 1a: a very potent macrolide antitumor agent.

Authors:  Arun K Ghosh; Hao Yuan
Journal:  Tetrahedron Lett       Date:  2009-04-01       Impact factor: 2.415

7.  Toxicity Bioassay and Cytotoxic Effects of the Benthic Marine Dinoflagellate Amphidinium operculatum.

Authors:  Ana Luisa Mejía-Camacho; Lorena María Durán-Riveroll; Allan Douglas Cembella
Journal:  J Xenobiot       Date:  2021-04-27

8.  Genetic diversity, morphological uniformity and polyketide production in dinoflagellates (Amphidinium, Dinoflagellata).

Authors:  Shauna A Murray; Tamsyn Garby; Mona Hoppenrath; Brett A Neilan
Journal:  PLoS One       Date:  2012-06-04       Impact factor: 3.240

9.  Levantilides A and B, 20-membered macrolides from a Micromonospora strain isolated from the Mediterranean deep sea sediment.

Authors:  Andrea Gärtner; Birgit Ohlendorf; Dirk Schulz; Heidi Zinecker; Jutta Wiese; Johannes F Imhoff
Journal:  Mar Drugs       Date:  2011-01-14       Impact factor: 5.118

Review 10.  Marine-Derived Macrolides 1990-2020: An Overview of Chemical and Biological Diversity.

Authors:  Hairong Zhang; Jiabin Zou; Xiaoxue Yan; Junlong Chen; Xiujiao Cao; Jialing Wu; Yinghui Liu; Tingting Wang
Journal:  Mar Drugs       Date:  2021-03-25       Impact factor: 5.118

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.