AIMS: To evaluate the presence of peripapillary retinal nerve fibre layer (RNFL) defects in patients with Stargardt disease by using spectral-domain optical coherence tomography (SD-OCT). METHODS: Fifty-two eyes of 27 patients with Stargardt disease underwent peripapillary RNFL thickness measurements using SD-OCT. RESULTS: Twenty-seven patients with Stargardt disease were enrolled. Their mean (±SD) age was 38.3 (14.7) years. Fourteen patients (51.9%) showed a thinning of the peripapillary RNFL in one or more quadrants in at least one eye, and four patients (14.8%) in both eyes. Five patients (18.5%) showed a thickening of the peripapillary RNFL in at least one eye, and four patients (14.8%) in both eyes. CONCLUSION: This study demonstrated the presence of defects in the peripapillary RNFL thickness in patients with Stargardt disease by using SD-OCT. It would be clinically prudent that Stargardt patients considered for various treatment options be considered for RNFL thickness measurements.
AIMS: To evaluate the presence of peripapillary retinal nerve fibre layer (RNFL) defects in patients with Stargardt disease by using spectral-domain optical coherence tomography (SD-OCT). METHODS: Fifty-two eyes of 27 patients with Stargardt disease underwent peripapillary RNFL thickness measurements using SD-OCT. RESULTS: Twenty-seven patients with Stargardt disease were enrolled. Their mean (±SD) age was 38.3 (14.7) years. Fourteen patients (51.9%) showed a thinning of the peripapillary RNFL in one or more quadrants in at least one eye, and four patients (14.8%) in both eyes. Five patients (18.5%) showed a thickening of the peripapillary RNFL in at least one eye, and four patients (14.8%) in both eyes. CONCLUSION: This study demonstrated the presence of defects in the peripapillary RNFL thickness in patients with Stargardt disease by using SD-OCT. It would be clinically prudent that Stargardt patients considered for various treatment options be considered for RNFL thickness measurements.
Authors: J Kaplan; S Gerber; D Larget-Piet; J M Rozet; H Dollfus; J L Dufier; S Odent; A Postel-Vinay; N Janin; M L Briard Journal: Nat Genet Date: 1993-11 Impact factor: 38.330
Authors: A Maugeri; B J Klevering; K Rohrschneider; A Blankenagel; H G Brunner; A F Deutman; C B Hoyng; F P Cremers Journal: Am J Hum Genet Date: 2000-08-24 Impact factor: 11.025
Authors: Tomas R Burke; David W Rhee; R Theodore Smith; Stephen H Tsang; Rando Allikmets; Stanley Chang; Margot A Lazow; Donald C Hood; Vivienne C Greenstein Journal: Invest Ophthalmol Vis Sci Date: 2011-10-10 Impact factor: 4.799
Authors: Jason C Park; Frederick T Collison; Gerald A Fishman; Rando Allikmets; Jana Zernant; Michelle Liu; J Jason McAnany Journal: Invest Ophthalmol Vis Sci Date: 2015-07 Impact factor: 4.799
Authors: Grace E Boynton; Maxwell S Stem; Leon Kwark; Gregory R Jackson; Sina Farsiu; Thomas W Gardner Journal: Ophthalmology Date: 2015-01-17 Impact factor: 12.079
Authors: S Scott Whitmore; Christopher R Fortenbach; Justine L Cheng; Adam P DeLuca; D Brice Critser; Elizabeth L Geary; Jeremy M Hoffmann; Edwin M Stone; Ian C Han Journal: Sci Rep Date: 2020-10-06 Impact factor: 4.379