Literature DB >> 209310

Catabolite modulator factor: physiological properties and in vivo effects.

A Dessein, F Tillier, A Ullmann.   

Abstract

Catabolite modulator factor (CMF) specifically inhibits the expression of operons sensitive to catabolite repression. Systems known to be catabolite independent are not affected by CMF. The rate of metabolism of CMF depends on the extent of catabolite repression: it is slow under conditions of strong repression and high in catabolically derepressed cells. Cyclic AMP does not interfere with the rate of CMF metabolism. It has been found that a certain class of crp mutants are partially resistant to the repressive effect of CMF. Our results provide considerable support for the existence of an additional negative control in the regulation of catabolite repression.

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Year:  1978        PMID： 209310     DOI： 10.1007/bf00333854

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  6 in total

1.  [REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF THE ENZYMES OF GALACTOSE METABOLISM IN ESCHERICHIA COLI K 12. I. THE INDUCED BIOSYNTHESIS OF GALACTOKINASE AND THE SIMULTANEOUS INDUCTION OF THE ENZYMATIC SEQUENCE].

Authors:  G BUTTIN
Journal:  J Mol Biol       Date:  1963-08       Impact factor: 5.469

2.  PROPERTIES OF CRYSTALLINE TRYPTOPHANASE.

Authors:  W A NEWTON; Y MORINO; E E SNELL
Journal:  J Biol Chem       Date:  1965-03       Impact factor: 5.157

3.  Catabolite modulator factor: a possible mediator of catabolite repression in bacteria.

Authors:  A Ullmann; F Tillier; J Monod
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

4.  Catabolite repression in Escherichia coli mutants lacking cyclic AMP.

Authors:  A Dessein; M Schwartz; A Ullmann
Journal:  Mol Gen Genet       Date:  1978-06-01

5.  Lac repressor can be fused to beta-galactosidase.

Authors:  B Müller-Hill; J Kania
Journal:  Nature       Date:  1974-06-07       Impact factor: 49.962

6.  Phosphoglucomutase mutants of Escherichia coli K-12.

Authors:  S Adhya; M Schwartz
Journal:  J Bacteriol       Date:  1971-11       Impact factor: 3.490
  6 in total
  8 in total

1.  Isolation and characterization of an endogenous inhibitor of protein synthesis in Escherichia coli K-12.

Authors:  V L Clark
Journal:  J Bacteriol       Date:  1979-01       Impact factor: 3.490

2.  Regulation of lac operon expression: reappraisal of the theory of catabolite repression.

Authors:  B L Wanner; R Kodaira; F C Neidhardt
Journal:  J Bacteriol       Date:  1978-12       Impact factor: 3.490

Review 3.  Cyclic nucleotides in procaryotes.

Authors:  J L Botsford
Journal:  Microbiol Rev       Date:  1981-12

4.  Involvement of cyclic AMP and its receptor protein in the sensitivity of Escherichia coli K 12 toward serine: excretion of 2-ketobutyrate, a precursor of isoleucine.

Authors:  J Daniel; A Danchin
Journal:  Mol Gen Genet       Date:  1979-11

5.  Metabolite gene regulation: imidazole and imidazole derivatives which circumvent cyclic adenosine 3',5'-monophosphate in induction of the Escherichia coli L-arabinose operon.

Authors:  E L Kline; V A Bankaitis; C S Brown; D C Montefiori
Journal:  J Bacteriol       Date:  1980-02       Impact factor: 3.490

6.  Anomalous expression of the E. coli lac operon in Proteus mirabilis. I. Effects of L8 and L8 UV5.

Authors:  M Roberts; S Baumberg
Journal:  Mol Gen Genet       Date:  1984

7.  Isolation and characterization of cAMP suppressor mutants of Escherichia coli K12.

Authors:  T Melton; L L Snow; C S Freitag; W J Dobrogosz
Journal:  Mol Gen Genet       Date:  1981

8.  Regulatory interactions among the cya, crp and pts gene products in Salmonella typhimurium.

Authors:  W J Dobrogosz; G W Hall; D K Sherba; D O Silva; J G Harman; T Melton
Journal:  Mol Gen Genet       Date:  1983
  8 in total

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