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Literature DB >> 6318040

Regulatory interactions among the cya, crp and pts gene products in Salmonella typhimurium.

W J Dobrogosz, G W Hall, D K Sherba, D O Silva, J G Harman, T Melton.

Abstract

A well-characterized set of pts deletion mutants of Salmonella typhimurium were used to re-evaluate the purported role of the PTS in the inducer exclusion process and in regulation cAMP synthesis. During the course of these studies a class of secondary mutations was isolated which suppress the inhibition of cAMP synthesis caused by pts mutations. These suppressor mutations were traced to the crp locus and tentatively designated as acr (adenylate cyclase regulation) mutations. A new model is proposed in which CRP rather than adenylate cyclase is believed to be the central regulatory element in the catabolite repression phenomenon.

Entities: Chemical Species

Mesh：

Substances：
Cyclic AMP

Year: 1983 PMID： 6318040 DOI： 10.1007/bf00392194

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

47 in total

1. Culic 3', 5', -adenosine monophosphate and catabolic repression in Escherichia coli.

Authors: J Náprstek; J Janecek; J Spizek; Z Dobrová
Journal: Biochem Biophys Res Commun Date: 1975-01-02 Impact factor: 3.575

2. Determination of the rates of synthesis and degradation of adenosine 3',5'-cyclic monophosphate in Escherichia coli CRP- and CRP+ strains.

Authors: A D Fraser; H Yamazaki
Journal: Can J Biochem Date: 1978-09

3. Abnormally high rate of cyclic AMP excretion from an Escherichia coli mutant deficient in cyclic AMP receptor protein.

Authors: K Potter; G Chaloner-Larsson; H Yamazaki
Journal: Biochem Biophys Res Commun Date: 1974-03-25 Impact factor: 3.575

9. Sugar transport. 2nducer exclusion and regulation of the melibiose, maltose, glycerol, and lactose transport systems by the phosphoenolpyruvate:sugar phosphotransferase system.

Authors: M H Saier; S Roseman
Journal: J Biol Chem Date: 1976-11-10 Impact factor: 5.157

3. Cloning and DNA sequence analysis of the wild-type and mutant cyclic AMP receptor protein genes from Salmonella typhimurium.

Authors: C J Schroeder; W J Dobrogosz
Journal: J Bacteriol Date: 1986-08 Impact factor: 3.490

4. Phosphoenolpyruvate-sugar phosphotransferase transport system of Streptococcus mutans: purification of HPr and enzyme I and determination of their intracellular concentrations by rocket immunoelectrophoresis.

Authors: L Thibault; C Vadeboncoeur
Journal: Infect Immun Date: 1985-12 Impact factor: 3.441

5. A new pleiotropic mutation causing defective carbohydrate uptake in Escherichia coli K-12: isolation, mapping, and preliminary characterization.

Authors: S K Mahajan; N B Vartak; A R Datta
Journal: J Bacteriol Date: 1988-06 Impact factor: 3.490

6. Regulation of cyclic AMP synthesis by enzyme IIIGlc of the phosphoenolpyruvate:sugar phosphotransferase system in crp strains of Salmonella typhimurium.

Authors: J L den Blaauwen; P W Postma
Journal: J Bacteriol Date: 1985-10 Impact factor: 3.490

6 in total

Regulatory interactions among the cya, crp and pts gene products in Salmonella typhimurium.

1. Culic 3', 5', -adenosine monophosphate and catabolic repression in Escherichia coli.

2. Determination of the rates of synthesis and degradation of adenosine 3',5'-cyclic monophosphate in Escherichia coli CRP- and CRP+ strains.

3. Abnormally high rate of cyclic AMP excretion from an Escherichia coli mutant deficient in cyclic AMP receptor protein.

4. Sugar transport. I. Isolation of a phosphotransferase system from Escherichia coli.

5. Altered hexose transport and salt sensitivity in cyclic adenosine 3',5'-monophosphate-deficient Escherichia coli.

6. Effects of crp mutations on adenosine 3',5'-monophosphate metabolism in Salmonella typhimurium.

7. Metabolism of cyclic adenosine 3',5'-monophosphate and induction of tryptophanase in Escherichia coli.

8. Cyclic adenosine 3',5'-monophosphate regulation of membrane energetics in Escherichia coli.

9. Sugar transport. 2nducer exclusion and regulation of the melibiose, maltose, glycerol, and lactose transport systems by the phosphoenolpyruvate:sugar phosphotransferase system.

10. Catabolite repression and pyruvate metabolism in Escherichia coli.

Review 1. Linkage map of Salmonella typhimurium, edition VII.

Review 2. Phosphoenolpyruvate:carbohydrate phosphotransferase system of bacteria.

3. Cloning and DNA sequence analysis of the wild-type and mutant cyclic AMP receptor protein genes from Salmonella typhimurium.

4. Phosphoenolpyruvate-sugar phosphotransferase transport system of Streptococcus mutans: purification of HPr and enzyme I and determination of their intracellular concentrations by rocket immunoelectrophoresis.

5. A new pleiotropic mutation causing defective carbohydrate uptake in Escherichia coli K-12: isolation, mapping, and preliminary characterization.

6. Regulation of cyclic AMP synthesis by enzyme IIIGlc of the phosphoenolpyruvate:sugar phosphotransferase system in crp strains of Salmonella typhimurium.