Literature DB >> 209309

Catabolite repression in Escherichia coli mutants lacking cyclic AMP.

A Dessein, M Schwartz, A Ullmann.   

Abstract

The regulation of catabolite repression of beta-galactosidase has been studied in Escherichia coli mutants deleted for the adenyl cyclase gene (cya delta), and thus unable to synthesize cyclic AMP. It has been found that, provided a second mutation occurs either in the crp gene coding for the catabolite gene activator protein (CAP) or in the Lactose region, these mutants exhibit catabolite repression. If the catabolite repression seen in the mutant strains corresponds to the mechanism operating in wild-type cells the results would suggest that the intracellular concentration of cyclic AMP cannot be the unique regulator of catabolite repression.

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Year:  1978        PMID： 209309     DOI： 10.1007/bf00333853

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  5 in total

1.  Deletion of the Escherichia coli crp gene.

Authors:  D Sabourin; J Beckwith
Journal:  J Bacteriol       Date:  1975-04       Impact factor: 3.490

2.  Catabolite repression.

Authors:  B MAGASANIK
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1961

3.  Catabolite modulator factor: a possible mediator of catabolite repression in bacteria.

Authors:  A Ullmann; F Tillier; J Monod
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

4.  Genetic characterization of mutations which affect catabolite-sensitive operons in Escherichia coli, including deletions of the gene for adenyl cyclase.

Authors:  E Brickman; L Soll; J Beckwith
Journal:  J Bacteriol       Date:  1973-11       Impact factor: 3.490

5.  Cyclic adenosine monophosphate-independent mutants of the lactose operon of Escherichia coli.

Authors:  R Arditti; T Grodzicker; J Beckwith
Journal:  J Bacteriol       Date:  1973-05       Impact factor: 3.490
  5 in total
  25 in total

1.  Catabolite modulator factor: physiological properties and in vivo effects.

Authors:  A Dessein; F Tillier; A Ullmann
Journal:  Mol Gen Genet       Date:  1978-06-01

Review 2.  The catabolite repressor/activator (Cra) protein of enteric bacteria.

Authors:  M H Saier; T M Ramseier
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

3.  Regulation of expression of the crp gene of Escherichia coli K-12: in vivo study.

Authors:  P Cossart; B Gicquel-Sanzey
Journal:  J Bacteriol       Date:  1985-01       Impact factor: 3.490

4.  Generation of deletions in the 3'-flanking sequences of the Escherichia coli crp gene that induce cyclic AMP suppressor functions.

Authors:  J W Barton; T Melton
Journal:  J Bacteriol       Date:  1987-02       Impact factor: 3.490

5.  Regulation of lac operon expression: reappraisal of the theory of catabolite repression.

Authors:  B L Wanner; R Kodaira; F C Neidhardt
Journal:  J Bacteriol       Date:  1978-12       Impact factor: 3.490

6.  Multiple controls exerted on in vivo expression of the pepN gene in Escherichia coli: studies with pepN-lacZ operon and protein fusion strains.

Authors:  S Gharbi; A Belaich; M Murgier; A Lazdunski
Journal:  J Bacteriol       Date:  1985-09       Impact factor: 3.490

Review 7.  Cyclic nucleotides in procaryotes.

Authors:  J L Botsford
Journal:  Microbiol Rev       Date:  1981-12

8.  Mechanism of CRP-mediated cya suppression in Escherichia coli.

Authors:  J G Harman; W J Dobrogosz
Journal:  J Bacteriol       Date:  1983-01       Impact factor: 3.490

9.  Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein.

Authors:  C Guidi-Rontani; A Danchin; A Ullmann
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

10.  Regulation of adenylate cyclase synthesis in Escherichia coli: studies with cya-lac operon and protein fusion strains.

Authors:  V A Bankaitis; P J Bassford
Journal:  J Bacteriol       Date:  1982-09       Impact factor: 3.490
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