| Literature DB >> 20929811 |
Lyric C Bartholomay1, Robert M Waterhouse, George F Mayhew, Corey L Campbell, Kristin Michel, Zhen Zou, Jose L Ramirez, Suchismita Das, Kanwal Alvarez, Peter Arensburger, Bart Bryant, Sinead B Chapman, Yuemei Dong, Sara M Erickson, S H P Parakrama Karunaratne, Vladimir Kokoza, Chinnappa D Kodira, Patricia Pignatelli, Sang Woon Shin, Dana L Vanlandingham, Peter W Atkinson, Bruce Birren, George K Christophides, Rollie J Clem, Janet Hemingway, Stephen Higgs, Karine Megy, Hilary Ranson, Evgeny M Zdobnov, Alexander S Raikhel, Bruce M Christensen, George Dimopoulos, Marc A T Muskavitch.
Abstract
The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.Entities:
Mesh：
Year: 2010 PMID： 20929811 PMCID： PMC3104938 DOI： 10.1126/science.1193162
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728