| Literature DB >> 17588928 |
Robert M Waterhouse1, Evgenia V Kriventseva, Stephan Meister, Zhiyong Xi, Kanwal S Alvarez, Lyric C Bartholomay, Carolina Barillas-Mury, Guowu Bian, Stephanie Blandin, Bruce M Christensen, Yuemei Dong, Haobo Jiang, Michael R Kanost, Anastasios C Koutsos, Elena A Levashina, Jianyong Li, Petros Ligoxygakis, Robert M Maccallum, George F Mayhew, Antonio Mendes, Kristin Michel, Mike A Osta, Susan Paskewitz, Sang Woon Shin, Dina Vlachou, Lihui Wang, Weiqi Wei, Liangbiao Zheng, Zhen Zou, David W Severson, Alexander S Raikhel, Fotis C Kafatos, George Dimopoulos, Evgeny M Zdobnov, George K Christophides.
Abstract
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.Entities:
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Year: 2007 PMID： 17588928 PMCID： PMC2042107 DOI： 10.1126/science.1139862
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728