| Literature DB >> 12364793 |
George K Christophides1, Evgeny Zdobnov, Carolina Barillas-Mury, Ewan Birney, Stephanie Blandin, Claudia Blass, Paul T Brey, Frank H Collins, Alberto Danielli, George Dimopoulos, Charles Hetru, Ngo T Hoa, Jules A Hoffmann, Stefan M Kanzok, Ivica Letunic, Elena A Levashina, Thanasis G Loukeris, Gareth Lycett, Stephan Meister, Kristin Michel, Luis F Moita, Hans-Michael Müller, Mike A Osta, Susan M Paskewitz, Jean-Marc Reichhart, Andrey Rzhetsky, Laurent Troxler, Kenneth D Vernick, Dina Vlachou, Jennifer Volz, Christian von Mering, Jiannong Xu, Liangbiao Zheng, Peer Bork, Fotis C Kafatos.
Abstract
We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster. Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects' very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.Entities:
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Year: 2002 PMID： 12364793 DOI： 10.1126/science.1077136
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728