Literature DB >> 2091020

High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man.

T B Vree1, E W Beneken Kolmer, Y A Hekster.   

Abstract

A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, less than 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.

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Year:  1990        PMID： 2091020     DOI： 10.1007/BF01967825

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  23 in total

1.  [Evaluative bases for new sulfonamides].

Authors:  A M WALTER
Journal:  Chemotherapia (Basel)       Date:  1963

2.  Clinical pharmacokinetics of sulfonamides and their metabolites: an encyclopedia.

Authors:  T B Vree; Y A Hekster
Journal:  Antibiot Chemother (1971)       Date:  1987

3.  [Elimination, plasma protein binding, and dosage of some sulfonamides. II. Studies in cattle].

Authors:  P Tschudi
Journal:  Zentralbl Veterinarmed A       Date:  1973-03

4.  Studies on metabolism of drugs. 13. Quantitative separation of metabolites in human urine after oral administration of sulfisomezole and sulfaphenazole.

Authors:  M Ueda; K Orita; T Koizumi
Journal:  Chem Pharm Bull (Tokyo)       Date:  1972-09       Impact factor: 1.645

5.  O-demethylation and N4-acetylation of sulfadimethoxine by the snail Cepaea hortensis.

Authors:  T B Vree; M L Vree; E W Beneken Kolmer; Y A Hekster; M Shimoda; J F Nouws; T Yoshioka; K Hoji
Journal:  Nihon Juigaku Zasshi       Date:  1989-04

6.  Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man.

Authors:  T B Vree; E W Beneken Kolmer; M Martea; R Bosch; Y A Hekster; M Shimoda
Journal:  Pharm Weekbl Sci       Date:  1990-04-27

7.  Isolation and identification of 4-hydroxysulfamerazine and preliminary studies on its pharmacokinetics in dogs.

Authors:  T B Vree; M W Tijhuis; J F Nouws; Y A Hekster
Journal:  Pharm Weekbl Sci       Date:  1984-04-27

8.  Pharmacokinetics, N1-glucuronidation, and N4-acetylation of sulfa-6-monomethoxine in humans.

Authors:  T B Vree; E W Beneken Kolmer; Y A Hekster; M Shimoda; M Ono; T Miura
Journal:  Drug Metab Dispos       Date:  1990 Nov-Dec       Impact factor: 3.922

9.  Pharmacokinetics of sulphinpyrazone and its major metabolites after a single dose and during chronic treatment.

Authors:  F Schlicht; C Staiger; J de Vries; U Gundert-Remy; R Hildebrandt; J Harenberg; N S Wang; E Weber
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

10.  Species differences in the metabolism of sulphadimethoxine.

Authors:  J W Bridges; M R Kibby; S R Walker; R T Williams
Journal:  Biochem J       Date:  1968-10       Impact factor: 3.857
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  5 in total

1.  Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.

Authors:  S Kanamitsu; K Ito; Y Sugiyama
Journal:  Pharm Res       Date:  2000-03       Impact factor: 4.200

2.  Direct measurement of probenecid and its glucuronide conjugate by means of high pressure liquid chromatography in plasma and urine of humans.

Authors:  T B Vree; E W Beneken Kolmer
Journal:  Pharm Weekbl Sci       Date:  1992-06-19

3.  Direct gradient reversed-phase HPLC analysis and preliminary pharmacokinetics of nalidixic acid, 7-hydroxymethylnalidixic acid, 7-carboxynalidixic acid, and their corresponding glucuronide conjugates in humans.

Authors:  T B Vree; M van den Biggelaar-Martea; E W van Ewijk-Beneken Kolmer; Y A Hekster
Journal:  Pharm World Sci       Date:  1993-06-18

4.  Direct high pressure liquid chromatographic analysis and preliminary pharmacokinetics of enantiomers of oxazepam and temazepam with their corresponding glucuronide conjugates.

Authors:  T B Vree; A M Baars; E W Wuis
Journal:  Pharm Weekbl Sci       Date:  1991-04-26

5.  Capacity-limited renal glucuronidation of probenecid by humans. A pilot Vmax-finding study.

Authors:  T B Vree; E W Van Ewijk-Beneken Kolmer; E W Wuis; Y A Hekster
Journal:  Pharm Weekbl Sci       Date:  1992-10-16
  5 in total

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