Literature DB >> 2739212

O-demethylation and N4-acetylation of sulfadimethoxine by the snail Cepaea hortensis.

T B Vree, M L Vree, E W Beneken Kolmer, Y A Hekster, M Shimoda, J F Nouws, T Yoshioka, K Hoji.   

Abstract

The snail Cepaea hortensis O-dealkylates sulfadimethoxine at the 2- and 6-position, the 2-position being favoured. Sulfadimethoxine is also acetylated, while no measurable acetylation of the hydroxy (= demethyl) metabolites took place.

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Year:  1989        PMID: 2739212     DOI: 10.1292/jvms1939.51.364

Source DB:  PubMed          Journal:  Nihon Juigaku Zasshi        ISSN: 0021-5295


  3 in total

1.  High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man.

Authors:  T B Vree; E W Beneken Kolmer; Y A Hekster
Journal:  Pharm Weekbl Sci       Date:  1990-12-14

2.  Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man.

Authors:  T B Vree; E W Beneken Kolmer; M Martea; R Bosch; Y A Hekster; M Shimoda
Journal:  Pharm Weekbl Sci       Date:  1990-04-27

3.  Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfamethomidine in humans.

Authors:  T B Vree; E W Beneken Kolmer; Y A Hekster
Journal:  Pharm Weekbl Sci       Date:  1991-10-18
  3 in total

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