BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects. OBJECTIVE: To use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD. MATERIALS AND METHODS: Random forest modelling and a split-sample case-control approach were used to identify candidate predictors. RESULTS: We identified 1013 genes and one smoking exposure variable that differentiated current and former smokers with or without COPD. This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14). CONCLUSION: These gene expression profiles represent potential biomarkers for COPD and may help increase mechanistic understanding of the disease.
BACKGROUND:Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects. OBJECTIVE: To use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD. MATERIALS AND METHODS: Random forest modelling and a split-sample case-control approach were used to identify candidate predictors. RESULTS: We identified 1013 genes and one smoking exposure variable that differentiated current and former smokers with or without COPD. This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14). CONCLUSION: These gene expression profiles represent potential biomarkers for COPD and may help increase mechanistic understanding of the disease.
Authors: Ma'en Obeidat; Xiaoting Ding; Nick Fishbane; Zsuzsanna Hollander; Raymond T Ng; Bruce McManus; Scott J Tebbutt; Bruce E Miller; Stephen Rennard; Peter D Paré; Don D Sin Journal: Nicotine Tob Res Date: 2016-05-06 Impact factor: 4.244
Authors: Timothy M Bahr; Grant J Hughes; Michael Armstrong; Rick Reisdorph; Christopher D Coldren; Michael G Edwards; Christina Schnell; Ross Kedl; Daniel J LaFlamme; Nichole Reisdorph; Katerina J Kechris; Russell P Bowler Journal: Am J Respir Cell Mol Biol Date: 2013-08 Impact factor: 6.914
Authors: Dominik Reinhold; Jarrett D Morrow; Sean Jacobson; Junxiao Hu; Benjamin Ringel; Max A Seibold; Craig P Hersh; Katerina J Kechris; Russell P Bowler Journal: PLoS One Date: 2017-10-09 Impact factor: 3.240