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Literature DB >> 20886762

Protein homeostasis in models of aging and age-related conformational disease.

Elise A Kikis¹, Tali Gidalevitz, Richard I Morimoto.

Abstract

The stability of the proteome is crucial to the health of the cell, and contributes significantly to the lifespan of the organism. Aging and many age-related diseases have in common the expression of misfolded and damaged proteins. The chronic expression of damaged proteins during disease can have devastating consequences on protein homeostasis (proteostasis), resulting in disruption ofnumerous biological processes. This chapter discusses our current understanding of the various contributors to protein misfolding, and the mechanisms by which misfolding, and accompanied aggregation/toxicity, is accelerated by stress and aging. Invertebrate models have been instrumental in studying the processes related to aggregation and toxicity of disease-associated proteins and how dysregulation ofproteostasis leads to neurodegenerative diseases of aging.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：
Proteins

Year: 2010 PMID： 20886762 PMCID： PMC3402352 DOI： 10.1007/978-1-4419-7002-2_11

Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622

175 in total

Review 1. Oxidized protein degradation and repair in ageing and oxidative stress.

Authors: Bertrand Friguet
Journal: FEBS Lett Date: 2006-03-20 Impact factor: 4.124

Review 2. Molecular chaperones in cellular protein folding.

Authors: F U Hartl
Journal: Nature Date: 1996-06-13 Impact factor: 49.962

3. Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock.

Authors: C J Marcuccilli; S K Mathur; R I Morimoto; R J Miller
Journal: J Neurosci Date: 1996-01-15 Impact factor: 6.167

Review 4. Biological and chemical approaches to diseases of proteostasis deficiency.

Authors: Evan T Powers; Richard I Morimoto; Andrew Dillin; Jeffery W Kelly; William E Balch
Journal: Annu Rev Biochem Date: 2009 Impact factor: 23.643

5. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging.

Authors: Anat Ben-Zvi; Elizabeth A Miller; Richard I Morimoto
Journal: Proc Natl Acad Sci U S A Date: 2009-08-24 Impact factor: 11.205

6. Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.

Authors: Junsheng Yang; John Tower
Journal: J Gerontol A Biol Sci Med Sci Date: 2009-05-06 Impact factor: 6.053

Review 7. The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review.

Authors: Stuart K Calderwood; Ayesha Murshid; Thomas Prince
Journal: Gerontology Date: 2009-06-18 Impact factor: 5.140

8. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

Authors: G J Lithgow; T M White; S Melov; T E Johnson
Journal: Proc Natl Acad Sci U S A Date: 1995-08-01 Impact factor: 11.205

9. Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

Authors: C D Link
Journal: Proc Natl Acad Sci U S A Date: 1995-09-26 Impact factor: 11.205

10. Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity.

Authors: Tali Gidalevitz; Thomas Krupinski; Susana Garcia; Richard I Morimoto
Journal: PLoS Genet Date: 2009-03-06 Impact factor: 5.917

75 in total

Review 1. Genes against aging.

Authors: Richard A Miller
Journal: J Gerontol A Biol Sci Med Sci Date: 2012-03-28 Impact factor: 6.053

Review 2. The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease.

Authors: Virginija Jovaisaite; Laurent Mouchiroud; Johan Auwerx
Journal: J Exp Biol Date: 2014-01-01 Impact factor: 3.312

Protein homeostasis in models of aging and age-related conformational disease.

Review 1. Oxidized protein degradation and repair in ageing and oxidative stress.

Review 2. Molecular chaperones in cellular protein folding.

3. Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock.

Review 4. Biological and chemical approaches to diseases of proteostasis deficiency.

5. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging.

6. Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.

Review 7. The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review.

8. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

9. Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

10. Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity.

Review 1. Genes against aging.

Review 2. The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease.

3. Q-bodies monitor the quinary state of the protein fold.

4. Superior proteome stability in the longest lived animal.

Review 5. Relationship of electrophilic stress to aging.

6. Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis.

7. A novel interaction between aging and ER overload in a protein conformational dementia.

Review 8. FOXO transcription factors: key regulators of cellular quality control.

Review 9. Proteostasis and the aging proteome in health and disease.

10. Hypertonic stress induces rapid and widespread protein damage in C. elegans.