Literature DB >> 22459617

Genes against aging.

Richard A Miller1.   

Abstract

Individual mutations in mice can slow aging: They extend life span by retarding a wide range of harmful, age-dependent changes in multiple cells and tissues. Evolutionary changes-by definition, changes in DNA sequence-can lead to even more dramatic postponement of age-dependent deterioration. Genetic variation within a species, for example among breeds of dogs, can also lead to major changes in aging rate, although there is not yet any strong evidence for similar genetic variation that modulates aging in rodents or humans. This essay compares different strategies for using genetic information to clarify questions in biogerontology, suggesting an emphasis on genes that can retard multiple forms of age-dependent dysfunction in parallel.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22459617      PMCID： PMC6279231          DOI： 10.1093/gerona/gls082

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  46 in total

1.  Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant.

Authors:  Maggie Vergara; Michael Smith-Wheelock; James M Harper; Robert Sigler; Richard A Miller
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2004-12       Impact factor: 6.053

2.  Height and mortality in the counties of England and Wales.

Authors:  D J Barker; C Osmond; J Golding
Journal:  Ann Hum Biol       Date:  1990 Jan-Feb       Impact factor: 1.533

Review 3.  Optimality, mutation and the evolution of ageing.

Authors:  L Partridge; N H Barton
Journal:  Nature       Date:  1993-03-25       Impact factor: 49.962

4.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

Authors:  M Kuro-o; Y Matsumura; H Aizawa; H Kawaguchi; T Suga; T Utsugi; Y Ohyama; M Kurabayashi; T Kaname; E Kume; H Iwasaki; A Iida; T Shiraki-Iida; S Nishikawa; R Nagai; Y I Nabeshima
Journal:  Nature       Date:  1997-11-06       Impact factor: 49.962

Review 5.  Contemporary human genetic strategies in aging research.

Authors:  Cinnamon S Bloss; Ludmila Pawlikowska; Nicholas J Schork
Journal:  Ageing Res Rev       Date:  2010-08-10       Impact factor: 10.895

Review 6.  Premature aging in klotho mutant mice: cause or consequence?

Authors:  Beate Lanske; M Shawkat Razzaque
Journal:  Ageing Res Rev       Date:  2007-02-20       Impact factor: 10.895

7.  Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice.

Authors:  B A Kinney; K T Coschigano; J J Kopchick; R W Steger; A Bartke
Journal:  Physiol Behav       Date:  2001-04

Review 8.  Evolutionary medicine: from dwarf model systems to healthy centenarians?

Authors:  Valter D Longo; Caleb E Finch
Journal:  Science       Date:  2003-02-28       Impact factor: 47.728

9.  Demographic and clinical characteristics of geriatric horses: 467 cases (1989-1999).

Authors:  Margaret M Brosnahan; Mary Rose Paradis
Journal:  J Am Vet Med Assoc       Date:  2003-07-01       Impact factor: 1.936

10.  Adaptive threonine increase in transmembrane regions of mitochondrial proteins in higher primates.

Authors:  Yasuhiro Kitazoe; Hirohisa Kishino; Masami Hasegawa; Noriaki Nakajima; Jeffrey L Thorne; Masashi Tanaka
Journal:  PLoS One       Date:  2008-10-06       Impact factor: 3.240
View more
  14 in total

1.  The genetics of age-related health outcomes.

Authors:  Eileen M Crimmins; Caleb E Finch
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-03-27       Impact factor: 6.053

Review 2.  Mini-review: Retarding aging in murine genetic models of neurodegeneration.

Authors:  Roger L Albin; Richard A Miller
Journal:  Neurobiol Dis       Date:  2015-10-21       Impact factor: 5.996

3.  "IDEAL" aging is associated with lower resting metabolic rate: the Baltimore Longitudinal Study of Aging.

Authors:  Jennifer A Schrack; Nicolas D Knuth; Eleanor M Simonsick; Luigi Ferrucci
Journal:  J Am Geriatr Soc       Date:  2014-03-17       Impact factor: 5.562

4.  Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.

Authors:  Zoltan Ungvari; Zsuzsanna Tucsek; Danuta Sosnowska; Peter Toth; Tripti Gautam; Andrej Podlutsky; Agnes Csiszar; Gyorgy Losonczy; M Noa Valcarcel-Ares; William E Sonntag; Anna Csiszar
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-12-13       Impact factor: 6.053

5.  Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

Authors:  Anna Csiszar; Danuta Sosnowska; Zsuzsanna Tucsek; Tripti Gautam; Peter Toth; Gyorgy Losonczy; Ricki J Colman; Richard Weindruch; Rozalyn M Anderson; William E Sonntag; Zoltan Ungvari
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-08-17       Impact factor: 6.053

Review 6.  Articulating the Case for the Longevity Dividend.

Authors:  S Jay Olshansky
Journal:  Cold Spring Harb Perspect Med       Date:  2016-01-08       Impact factor: 6.915

Review 7.  Past, Present, and Future of Healthy Life Expectancy.

Authors:  Hiram Beltrán-Sánchez; Samir Soneji; Eileen M Crimmins
Journal:  Cold Spring Harb Perspect Med       Date:  2015-11-02       Impact factor: 6.915

Review 8.  The hallmarks of aging.

Authors:  Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

9.  Does Modulation of an Epigenetic Clock Define a Geroprotector?

Authors:  Nicholas J Schork; Brett Beaulieu-Jones; Winnie Liang; Susan Smalley; Laura H Goetz
Journal:  Adv Geriatr Med Res       Date:  2022-03-29

10.  Death by transposition - the enemy within?

Authors:  John M Sedivy; Jill A Kreiling; Nicola Neretti; Marco De Cecco; Steven W Criscione; Jeffrey W Hofmann; Xiaoai Zhao; Takahiro Ito; Abigail L Peterson
Journal:  Bioessays       Date:  2013-10-15       Impact factor: 4.345
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.