Literature DB >> 24084862

Q-bodies monitor the quinary state of the protein fold.

Daniela Martino Roth1, William E Balch.   

Abstract

Cytoplasmic compartments containing misfolded proteins targeted for degradation, named Q-bodies, have been identified. Q-body formation is a dynamic process that actively manages the metastable state of the protein fold through small heat shock proteins and the Hsp70-Hsp90-Hsp110 proteostasis system to promote cellular fitness under both physiological and stress conditions.

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Year:  2013        PMID： 24084862     DOI： 10.1038/ncb2857

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  23 in total

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Review 2.  Endoplasmic reticulum structure and interconnections with other organelles.

Authors:  Amber R English; Gia K Voeltz
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3.  Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation.

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4.  Reconstructing the Hsp90/Tau Machine.

Authors:  Umesh K Jinwal; John Koren; Chad A Dickey
Journal:  Curr Enzym Inhib       Date:  2013-01-01

Review 5.  Protein homeostasis in models of aging and age-related conformational disease.

Authors:  Elise A Kikis; Tali Gidalevitz; Richard I Morimoto
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

Review 6.  Proteostasis, an emerging therapeutic paradigm for managing inflammatory airway stress disease.

Authors:  M Bouchecareilh; W E Balch
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7.  The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.

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8.  A class of membrane proteins shaping the tubular endoplasmic reticulum.

Authors:  Gia K Voeltz; William A Prinz; Yoko Shibata; Julia M Rist; Tom A Rapoport
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9.  A chaperone trap contributes to the onset of cystic fibrosis.

Authors:  Judith A Coppinger; Darren M Hutt; Abbas Razvi; Atanas V Koulov; Sandra Pankow; John R Yates; William E Balch
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10.  Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.

Authors:  Stéphanie Escusa-Toret; Willianne I M Vonk; Judith Frydman
Journal:  Nat Cell Biol       Date:  2013-09-15       Impact factor: 28.824
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2.  Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [PSI+] prion formation.

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Review 3.  Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson's Disease.

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Review 4.  Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity.

Authors:  Shamini Vijayakumaran; Mathew B Wong; Helma Antony; Dean L Pountney
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5.  The ER Stress Surveillance (ERSU) pathway regulates daughter cell ER protein aggregate inheritance.

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  5 in total

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