Literature DB >> 20885394

Alzheimer's failure raises questions about disease-modifying strategies.

Andy Extance.   

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Year:  2010        PMID： 20885394     DOI： 10.1038/nrd3288

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  5 in total

1.  Hope builds for earlier detection of Alzheimer's disease.

Authors:  Alisa Opar
Journal:  Nat Rev Drug Discov       Date:  2010-08       Impact factor: 84.694

2.  Mixed results for disease-modification strategies for Alzheimer's disease.

Authors:  Alisa Opar
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

3.  Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

Authors:  Gen He; Wenjie Luo; Peng Li; Christine Remmers; William J Netzer; Joseph Hendrick; Karima Bettayeb; Marc Flajolet; Fred Gorelick; Lawrence P Wennogle; Paul Greengard
Journal:  Nature       Date:  2010-09-02       Impact factor: 49.962

4.  A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.

Authors:  Randall J Bateman; Eric R Siemers; Kwasi G Mawuenyega; Guolin Wen; Karen R Browning; Wendy C Sigurdson; Kevin E Yarasheski; Stuart W Friedrich; Ronald B Demattos; Patrick C May; Steven M Paul; David M Holtzman
Journal:  Ann Neurol       Date:  2009-07       Impact factor: 10.422

5.  Gleevec inhibits beta-amyloid production but not Notch cleavage.

Authors:  William J Netzer; Fei Dou; Dongming Cai; Darren Veach; Stephanie Jean; Yueming Li; William G Bornmann; Bayard Clarkson; Huaxi Xu; Paul Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-01       Impact factor: 11.205
  5 in total
  75 in total

1.  Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain.

Authors:  Madepalli K Lakshmana; Crystal D Hayes; Steven P Bennett; Elisabetta Bianchi; Konda M Reddy; Edward H Koo; David E Kang
Journal:  FASEB J       Date:  2012-01-31       Impact factor: 5.191

2.  Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.

Authors:  Ayodeji A Asuni; Maitea Guridi; Joanna E Pankiewicz; Sandrine Sanchez; Martin J Sadowski
Journal:  Ann Neurol       Date:  2014-04-28       Impact factor: 10.422

3.  L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease.

Authors:  Yu Zhang; Long-Jian Huang; Si Shi; Shao-Feng Xu; Xiao-Liang Wang; Ying Peng
Journal:  CNS Neurosci Ther       Date:  2016-07-20       Impact factor: 5.243

4.  Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.

Authors:  Yu Ohki; Takuya Higo; Kengo Uemura; Naoaki Shimada; Satoko Osawa; Oksana Berezovska; Satoshi Yokoshima; Tohru Fukuyama; Taisuke Tomita; Takeshi Iwatsubo
Journal:  EMBO J       Date:  2011-10-14       Impact factor: 11.598

Review 5.  Emerging patterns of somatic mutations in cancer.

Authors:  Ian R Watson; Koichi Takahashi; P Andrew Futreal; Lynda Chin
Journal:  Nat Rev Genet       Date:  2013-09-11       Impact factor: 53.242

Review 6.  Mechanisms of neural and behavioral dysfunction in Alzheimer's disease.

Authors:  Daniel W Wesson; Ralph A Nixon; Efrat Levy; Donald A Wilson
Journal:  Mol Neurobiol       Date:  2011-03-22       Impact factor: 5.590

Review 7.  Targeting γ-secretase in breast cancer.

Authors:  Jianxun Han; Qiang Shen
Journal:  Breast Cancer (Dove Med Press)       Date:  2012-06-21

Review 8.  Notch as a tumour suppressor.

Authors:  Craig S Nowell; Freddy Radtke
Journal:  Nat Rev Cancer       Date:  2017-02-03       Impact factor: 60.716

9.  Editorial: Translational Control of APP Expression for Alzheimer Disease Therapy.

Authors:  Joanna E Pankiewicz; Martin J Sadowski
Journal:  Ann Pharmacol Pharm       Date:  2017-08-18

Review 10.  Lessons learned from next-generation sequencing in head and neck cancer.

Authors:  Myriam Loyo; Ryan J Li; Chetan Bettegowda; Curtis R Pickering; Mitchell J Frederick; Jeffrey N Myers; Nishant Agrawal
Journal:  Head Neck       Date:  2012-08-21       Impact factor: 3.147
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