Literature DB >> 19172684

Mixed results for disease-modification strategies for Alzheimer's disease.

Alisa Opar.   

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Year:  2008        PMID： 19172684     DOI： 10.1038/nrd2676

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  16 in total

1.  Alzheimer's failure raises questions about disease-modifying strategies.

Authors:  Andy Extance
Journal:  Nat Rev Drug Discov       Date:  2010-10       Impact factor: 84.694

Review 2.  Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease.

Authors:  Qin Nie; Xiao-guang Du; Mei-yu Geng
Journal:  Acta Pharmacol Sin       Date:  2011-04-18       Impact factor: 6.150

Review 3.  APT drug R&D: the right active ingredient in the right presentation for the right therapeutic use.

Authors:  David Cavalla
Journal:  Nat Rev Drug Discov       Date:  2009-08-28       Impact factor: 84.694

4.  Protective effect of 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione, isolated from Averrhoa carambola L., against Aβ1-42-induced apoptosis in SH-SY5Y cells by reversing Bcl-2/Bax ratio.

Authors:  Shunyu Lu; Xiaojie Wei; Hongliang Zhang; Zhenfeng Chen; Juman Li; Xiaohui Xu; Qiuqiao Xie; Lixiu Chen; Fangxing Ye; Hoa Thi Thai Phama; Luhui Jiang; Tianmin Huang; Jinbin Wei; Renbin Huang
Journal:  Psychopharmacology (Berl)       Date:  2020-10-08       Impact factor: 4.530

5.  Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy.

Authors:  Chad Dickey; Clara Kraft; Umesh Jinwal; John Koren; Amelia Johnson; Laura Anderson; Lori Lebson; Daniel Lee; Dennis Dickson; Rohan de Silva; Lester I Binder; David Morgan; Jada Lewis
Journal:  Am J Pathol       Date:  2008-12-12       Impact factor: 4.307

6.  Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?

Authors:  Bruno P Imbimbo; Vincenzo Solfrizzi; Francesco Panza
Journal:  Front Aging Neurosci       Date:  2010-05-21       Impact factor: 5.750

7.  Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease.

Authors:  Jessica F Jordão; Carlos A Ayala-Grosso; Kelly Markham; Yuexi Huang; Rajiv Chopra; JoAnne McLaurin; Kullervo Hynynen; Isabelle Aubert
Journal:  PLoS One       Date:  2010-05-11       Impact factor: 3.240

8.  C-myb Plays an Essential Role in the Protective Function of IGF-1 on Cytotoxicity Induced by Aβ25-35 via the PI3K/Akt Pathway.

Authors:  Jingyu Zhang; Yongwei Shu; Yang Qu; Lina Zhang; Tingting Chu; Yonghui Zheng; Hong Zhao
Journal:  J Mol Neurosci       Date:  2017-11-06       Impact factor: 3.444

9.  The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.

Authors:  Grace Woodruff; Jessica E Young; Fernando J Martinez; Floyd Buen; Athurva Gore; Jennifer Kinaga; Zhe Li; Shauna H Yuan; Kun Zhang; Lawrence S B Goldstein
Journal:  Cell Rep       Date:  2013-11-14       Impact factor: 9.423

Review 10.  Chaperone signalling complexes in Alzheimer's disease.

Authors:  John Koren; Umesh K Jinwal; Daniel C Lee; Jeffrey R Jones; Cody L Shults; Amelia G Johnson; Laura J Anderson; Chad A Dickey
Journal:  J Cell Mol Med       Date:  2009-04       Impact factor: 5.310
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