Literature DB >> 3879659

Evolution of plasmid-coded resistance to broad-spectrum cephalosporins.

C Kliebe, B A Nies, J F Meyer, R M Tolxdorff-Neutzling, B Wiedemann.   

Abstract

A clinical isolate of Klebsiella ozaenae with transferable resistance to broad-spectrum cephalosporins produces a beta-lactamase determined by plasmid pBP60. The beta-lactamase had the same isoelectric point as SHV-1 (7.6). From heteroduplex analysis, an extensive homology between the two bla genes could be deduced; therefore, the new beta-lactamase was designated SHV-2. Enzymatic studies revealed that SHV-2 was able to hydrolyze broad-spectrum cephalosporins due to an increased affinity of these compounds for the enzyme. The assumption that SHV-2 is a natural mutant of SHV-1 was strongly supported by the isolation of a laboratory mutant of SHV-1 that showed activities similar to those of SHV-2.

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Year:  1985        PMID： 3879659      PMCID： PMC180236          DOI： 10.1128/AAC.28.2.302

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  beta-lactamase stability of HR 756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin.

Authors:  K P Fu; H C Neu
Journal:  Antimicrob Agents Chemother       Date:  1978-09       Impact factor: 5.191

2.  Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.

Authors:  A C Chang; S N Cohen
Journal:  J Bacteriol       Date:  1978-06       Impact factor: 3.490

3.  Types of beta-lactamase determined by plasmids in gram-negative bacteria.

Authors:  M Matthew; R W Hedges; J T Smith
Journal:  J Bacteriol       Date:  1979-06       Impact factor: 3.490

4.  R factor-mediated and chromosomal resistance to ampicillin in Escherichia coli.

Authors:  A Roupas; J S Pitton
Journal:  Antimicrob Agents Chemother       Date:  1974-02       Impact factor: 5.191

Review 5.  Pedigrees of some mutant strains of Escherichia coli K-12.

Authors:  B J Bachmann
Journal:  Bacteriol Rev       Date:  1972-12

6.  [Kinetic study of 2 beta lactamases responsible for the same phenotype].

Authors:  R Labia; F Le Goffic; J Andrillon
Journal:  Biochimie       Date:  1974       Impact factor: 4.079

7.  Microiodometric determination of beta-lactamase activity.

Authors:  R B Sykes; K Nordström
Journal:  Antimicrob Agents Chemother       Date:  1972-02       Impact factor: 5.191

8.  Directed selective pressure on a beta-lactamase to analyse molecular changes involved in development of enzyme function.

Authors:  A Hall; J R Knowles
Journal:  Nature       Date:  1976 Dec 23-30       Impact factor: 49.962

9.  Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility.

Authors:  R W Hedges; N Datta; P Kontomichalou; J T Smith
Journal:  J Bacteriol       Date:  1974-01       Impact factor: 3.490

10.  Properties of a R factor which originated in Pseudomonas aeruginosa 1822.

Authors:  J Grinsted; J R Saunders; L C Ingram; R B Sykes; M H Richmond
Journal:  J Bacteriol       Date:  1972-05       Impact factor: 3.490
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  114 in total

1.  Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.

Authors:  P A Bradford
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

Review 2.  Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.

Authors:  P A Bradford
Journal:  Clin Microbiol Rev       Date:  2001-10       Impact factor: 26.132

3.  Real-time PCR and melting curve analysis for reliable and rapid detection of SHV extended-spectrum beta-lactamases.

Authors:  C C Randegger; H Hächler
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

4.  Contribution of natural amino acid substitutions in SHV extended-spectrum beta-lactamases to resistance against various beta-lactams.

Authors:  C C Randegger; A Keller; M Irla; A Wada; H Hächler
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

5.  Comparison of screening methods for detection of extended-spectrum beta-lactamases and their prevalence among blood isolates of Escherichia coli and Klebsiella spp. in a Belgian teaching hospital.

Authors:  E Vercauteren; P Descheemaeker; M Ieven; C C Sanders; H Goossens
Journal:  J Clin Microbiol       Date:  1997-09       Impact factor: 5.948

Review 6.  Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes.

Authors:  R Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191

7.  Clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases: prevalence of CTX-M-3 at a hospital in China.

Authors:  Hui Wang; Swathi Kelkar; Weiyuan Wu; Minjun Chen; John P Quinn
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

8.  Cloning of SHV-2, OHIO-1, and OXA-6 beta-lactamases and cloning and sequencing of SHV-1 beta-lactamase.

Authors:  J Mercier; R C Levesque
Journal:  Antimicrob Agents Chemother       Date:  1990-08       Impact factor: 5.191

9.  Resistance to broad-spectrum antibiotics in aquatic systems: anthropogenic activities modulate the dissemination of bla(CTX-M)-like genes.

Authors:  Marta Tacão; António Correia; Isabel Henriques
Journal:  Appl Environ Microbiol       Date:  2012-04-06       Impact factor: 4.792

10.  Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.

Authors:  C Hal Jones; Alexey Ruzin; Margareta Tuckman; Melissa A Visalli; Peter J Petersen; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191
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