Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Optogenetic control of heart muscle in vitro and in vivo.

Literature DB >> 20881965

Optogenetic control of heart muscle in vitro and in vivo.

Tobias Bruegmann¹, Daniela Malan, Michael Hesse, Thomas Beiert, Christopher J Fuegemann, Bernd K Fleischmann, Philipp Sasse.

Abstract

Electrical stimulation is the standard technique for exploring electrical behavior of heart muscle, but this approach has considerable technical limitations. Here we report expression of the light-activated cation channel channelrhodopsin-2 for light-induced stimulation of heart muscle in vitro and in mice. This method enabled precise localized stimulation and constant prolonged depolarization of cardiomyocytes and cardiac tissue resulting in alterations of pacemaking, Ca(2+) homeostasis, electrical coupling and arrhythmogenic spontaneous extrabeats.

Entities: Chemical Disease Species

Mesh：

Substances：
Channelrhodopsins
Calcium

Year: 2010 PMID： 20881965 DOI： 10.1038/nmeth.1512

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

19 in total

Review 1. Electrical stimulation of excitable tissue: design of efficacious and safe protocols.

Authors: Daniel R Merrill; Marom Bikson; John G R Jefferys
Journal: J Neurosci Methods Date: 2005-02-15 Impact factor: 2.390

2. Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses.

Authors: Georg Nagel; Martin Brauner; Jana F Liewald; Nona Adeishvili; Ernst Bamberg; Alexander Gottschalk
Journal: Curr Biol Date: 2005-12-20 Impact factor: 10.834

3. Millisecond-timescale, genetically targeted optical control of neural activity.

Authors: Edward S Boyden; Feng Zhang; Ernst Bamberg; Georg Nagel; Karl Deisseroth
Journal: Nat Neurosci Date: 2005-08-14 Impact factor: 24.884

4. Spatial changes in transmembrane potential during extracellular electrical shocks in cultured monolayers of neonatal rat ventricular myocytes.

Authors: A M Gillis; V G Fast; S Rohr; A G Kléber
Journal: Circ Res Date: 1996-10 Impact factor: 17.367

5. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.

Authors: B O'Rourke; D A Kass; G F Tomaselli; S Kääb; R Tunin; E Marbán
Journal: Circ Res Date: 1999-03-19 Impact factor: 17.367

6. Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.

Authors: V A Maltsev; A M Wobus; J Rohwedel; M Bader; J Hescheler
Journal: Circ Res Date: 1994-08 Impact factor: 17.367

7. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.

Authors: Georg Nagel; Tanjef Szellas; Wolfram Huhn; Suneel Kateriya; Nona Adeishvili; Peter Berthold; Doris Ollig; Peter Hegemann; Ernst Bamberg
Journal: Proc Natl Acad Sci U S A Date: 2003-11-13 Impact factor: 11.205

8. Embryonic stem cells alone are able to support fetal development in the mouse.

Authors: A Nagy; E Gócza; E M Diaz; V R Prideaux; E Iványi; M Markkula; J Rossant
Journal: Development Date: 1990-11 Impact factor: 6.868

9. Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.

Authors: Eugen Kolossov; Toktam Bostani; Wilhelm Roell; Martin Breitbach; Frank Pillekamp; Jens M Nygren; Philipp Sasse; Olga Rubenchik; Jochen W U Fries; Daniela Wenzel; Caroline Geisen; Ying Xia; Zhongju Lu; Yaqi Duan; Ralf Kettenhofen; Stefan Jovinge; Wilhelm Bloch; Heribert Bohlen; Armin Welz; Juergen Hescheler; Sten Eirik Jacobsen; Bernd K Fleischmann
Journal: J Exp Med Date: 2006-09-05 Impact factor: 14.307

10. Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells.

Authors: Philipp Sasse; Jianbao Zhang; Lars Cleemann; Martin Morad; Juergen Hescheler; Bernd K Fleischmann
Journal: J Gen Physiol Date: 2007-08 Impact factor: 4.086

158 in total

1. Bioinformatic and mutational analysis of channelrhodopsin-2 protein cation-conducting pathway.

Authors: Anna Pia Plazzo; Nicola De Franceschi; Francesca Da Broi; Francesco Zonta; Maria Federica Sanasi; Francesco Filippini; Marco Mongillo
Journal: J Biol Chem Date: 2011-12-02 Impact factor: 5.157

2. Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns.

Authors: Eijiro Miyako; Tomonori Deguchi; Yoshihiro Nakajima; Masako Yudasaka; Yoshihisa Hagihara; Masanori Horie; Mototada Shichiri; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida; Yasushi Shigeri; Yasukazu Yoshida; Sumio Iijima
Journal: Proc Natl Acad Sci U S A Date: 2012-04-23 Impact factor: 11.205

3. Local gene targeting and cell positioning using magnetic nanoparticles and magnetic tips: comparison of mathematical simulations with experiments.

Authors: Carsten Kilgus; Alexandra Heidsieck; Annika Ottersbach; Wilhelm Roell; Christina Trueck; Bernd K Fleischmann; Bernhard Gleich; Philipp Sasse
Journal: Pharm Res Date: 2011-12-30 Impact factor: 4.200

Optogenetic control of heart muscle in vitro and in vivo.

Review 1. Electrical stimulation of excitable tissue: design of efficacious and safe protocols.

2. Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses.

3. Millisecond-timescale, genetically targeted optical control of neural activity.

4. Spatial changes in transmembrane potential during extracellular electrical shocks in cultured monolayers of neonatal rat ventricular myocytes.

5. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.

6. Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.

7. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.

8. Embryonic stem cells alone are able to support fetal development in the mouse.

9. Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.

10. Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells.

1. Bioinformatic and mutational analysis of channelrhodopsin-2 protein cation-conducting pathway.

2. Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns.

3. Local gene targeting and cell positioning using magnetic nanoparticles and magnetic tips: comparison of mathematical simulations with experiments.

4. Functional expression and modulation of the L-type Ca2+ current in embryonic heart cells.

5. Pacing lightly: optogenetics gets to the heart.

6. Computational Optogenetics: A Novel Continuum Framework for the Photoelectrochemistry of Living Systems.

Review 7. Tissue-Engineering for the Study of Cardiac Biomechanics.

Review 8. Optogenetics enlightens neuroscience drug discovery.

9. Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.

10. Optical pacing of the adult rabbit heart.