Literature DB >> 22639002

Functional expression and modulation of the L-type Ca2+ current in embryonic heart cells.

Daniela Malan1, Bernd K Fleischmann.   

Abstract

Voltage-dependent L-type Ca2+ channels (VDCCs) are critically involved in excitation contraction coupling and regulation of the force of contraction. An important mechanism contributing to the adaptation of heart function is modulation of the L-type Ca2+ current (I(Ca-L)) by hormones of the autonomous nervous system. The signaling pathways underlying this regulation in the adult heart are well understood. However, VDCC expression and its regulation in the embryonic heart are less understood. This report therefore provides a short overview of the current knowledge on this topic using embryonic stem cells and the mouse as model systems.

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Year:  2012        PMID： 22639002     DOI： 10.1007/s00246-012-0360-2

Source DB:  PubMed          Journal:  Pediatr Cardiol        ISSN： 0172-0643            Impact factor:   1.655


  46 in total

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Authors:  J Hescheler; B K Fleischmann; M Wartenberg; W Bloch; E Kolossov; G Ji; K Addicks; H Sauer
Journal:  Cells Tissues Organs       Date:  1999       Impact factor: 2.481

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Journal:  Eur J Pharmacol       Date:  1979-10-01       Impact factor: 4.432

3.  Production of mouse chimeras by aggregating pluripotent stem cells with embryos.

Authors:  Andras Nagy; Kristina Nagy; Marina Gertsenstein
Journal:  Methods Enzymol       Date:  2010       Impact factor: 1.600

4.  Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes.

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Journal:  FASEB J       Date:  2005-01-19       Impact factor: 5.191

5.  Adenylate cyclase and beta adrenergic receptor development in the mouse heart.

Authors:  F C Chen; H I Yamamura; W R Roeske
Journal:  J Pharmacol Exp Ther       Date:  1982-07       Impact factor: 4.030

6.  Developmental changes in beta-adrenoceptors, muscarinic cholinoceptors and Ca2+ channels in rat ventricular muscles.

Authors:  M Kojima; T Ishima; N Taniguchi; K Kimura; H Sada; N Sperelakis
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

7.  Muscarinic inhibitory and stimulatory regulation of the L-type Ca2+ current is not altered in cardiac ventricular myocytes from mice lacking endothelial nitric oxide synthase.

Authors:  A E Belevych; R D Harvey
Journal:  J Physiol       Date:  2000-10-15       Impact factor: 5.182

8.  Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.

Authors:  V A Maltsev; A M Wobus; J Rohwedel; M Bader; J Hescheler
Journal:  Circ Res       Date:  1994-08       Impact factor: 17.367

9.  Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development.

Authors:  Bernd K Fleischmann; Yaqi Duan; Yun Fan; Torsten Schoneberg; Andreas Ehlich; Nibedita Lenka; Serge Viatchenko-Karpinski; Lutz Pott; Juergen Hescheler; Bernd Fakler
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

10.  Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Authors:  A Nagy; J Rossant; R Nagy; W Abramow-Newerly; J C Roder
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205
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