Literature DB >> 20871149

Spasticity: revisiting the role and the individual value of several pharmacological treatments.

Eric Lapeyre1, Jan B M Kuks, Willem J Meijler.   

Abstract

Though in the last few decades only a few new drugs have come available for the treatment of spasticity, new insights may revise the role and individual value of several pharmacological treatments. Diazepam, baclofen and tizanidine are the most prescribed drugs for the treatment of spasticity. Intrathecal baclofen and local infiltration of botulin toxin are added values in selective patients. Gabapentin is a novelty, and the working mechanism of cannabis has been elucidated. Dantrolene sodium appears to owe its selectivity from the recently discovered ryanodine receptor, with a peripheral effect in muscles. In this review the pathophysiology and epidemiology of spasticity, pharmacology, clinical efficacy and unwanted effects of the different drugs for spasticity are updated.

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Year:  2010        PMID： 20871149     DOI： 10.3233/NRE-2010-0596

Source DB:  PubMed          Journal:  NeuroRehabilitation        ISSN： 1053-8135            Impact factor:   2.138


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