Talal Aboud1, Nathaniel M Schuster2. 1. Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA. taboud@uthsc.edu. 2. Center for Pain Medicine, Department of Anesthesiology, University of California, San Diego, CA, USA.
Abstract
PURPOSE OF REVIEW: Multiple Sclerosis (MS) is a chronic autoimmune disease with no curative treatment available. While recent years have ushered in many effective new disease-modifying therapies for MS, they have not obviated the need for symptomatic treatments for MS-related pain. In this review, we discuss available approaches to control pain, which is one of the most common complaints MS patients have. RECENT FINDINGS: The most recent research in this topic is directed towards non-pharmacologic interventions including water exercises, yoga and cannabis. More trials are being conducted on neuromodulation for MS-related neuropathic pain, including transcutaneous electrical nerve stimulation (TENS) and transcranial direct current stimulation (tDCS). Pain control for MS patients is challenging, considering the progressive and relapsing remitting nature of the disease, however, it is a very important aspect of it's management, as it improves mobility, exercise tolerance, concomitant depression and overall quality of life. Future research should focus on the use of neuromodulation in controlling MS pain.
PURPOSE OF REVIEW: Multiple Sclerosis (MS) is a chronic autoimmune disease with no curative treatment available. While recent years have ushered in many effective new disease-modifying therapies for MS, they have not obviated the need for symptomatic treatments for MS-related pain. In this review, we discuss available approaches to control pain, which is one of the most common complaints MSpatients have. RECENT FINDINGS: The most recent research in this topic is directed towards non-pharmacologic interventions including water exercises, yoga and cannabis. More trials are being conducted on neuromodulation for MS-related neuropathic pain, including transcutaneous electrical nerve stimulation (TENS) and transcranial direct current stimulation (tDCS). Pain control for MSpatients is challenging, considering the progressive and relapsing remitting nature of the disease, however, it is a very important aspect of it's management, as it improves mobility, exercise tolerance, concomitant depression and overall quality of life. Future research should focus on the use of neuromodulation in controlling MSpain.
Entities:
Keywords:
Central neuropathic pain; MS disability; MS pain; Multiple sclerosis; Pain; Spasticity
Authors: Morena Brazil Sant'Anna; Aline C Giardini; Marcio A C Ribeiro; Flavia S R Lopes; Nathalia B Teixeira; Louise F Kimura; Michelle C Bufalo; Orlando G Ribeiro; Andrea Borrego; Wafa H K Cabrera; Julio C B Ferreira; Vanessa O Zambelli; Osvaldo A Sant'Anna; Gisele Picolo Journal: Front Immunol Date: 2020-10-28 Impact factor: 7.561