OBJECTIVES: We prospectively examined nonrecreational physical activity and sedentary behavior in relation to breast cancer risk among 97 039 postmenopausal women in the National Institutes of Health-AARP Diet and Health Study. METHODS: We identified 2866 invasive and 570 in situ breast cancer cases recorded between 1996 and 2003 and used Cox proportional hazards regression to estimate multivariate relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: Routine activity during the day at work or at home that included heavy lifting or carrying versus mostly sitting was associated with reduced risk of invasive breast cancer (RR = 0.62; 95% CI = 0.42, 0.91; P(trend) = .024). CONCLUSIONS: Routine activity during the day at work or home may be related to reduced invasive breast cancer risk. Domains outside of recreation time may be attractive targets for increasing physical activity and reducing sedentary behavior among postmenopausal women.
OBJECTIVES: We prospectively examined nonrecreational physical activity and sedentary behavior in relation to breast cancer risk among 97 039 postmenopausal women in the National Institutes of Health-AARP Diet and Health Study. METHODS: We identified 2866 invasive and 570 in situ breast cancer cases recorded between 1996 and 2003 and used Cox proportional hazards regression to estimate multivariate relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: Routine activity during the day at work or at home that included heavy lifting or carrying versus mostly sitting was associated with reduced risk of invasive breast cancer (RR = 0.62; 95% CI = 0.42, 0.91; P(trend) = .024). CONCLUSIONS: Routine activity during the day at work or home may be related to reduced invasive breast cancer risk. Domains outside of recreation time may be attractive targets for increasing physical activity and reducing sedentary behavior among postmenopausal women.
Authors: Charles E Matthews; Kong Y Chen; Patty S Freedson; Maciej S Buchowski; Bettina M Beech; Russell R Pate; Richard P Troiano Journal: Am J Epidemiol Date: 2008-02-25 Impact factor: 4.897
Authors: Heather K Neilson; Christine M Friedenreich; Nigel T Brockton; Robert C Millikan Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-01 Impact factor: 4.254
Authors: Stephanie M George; Steven C Moore; Wong-Ho Chow; Arthur Schatzkin; Albert R Hollenbeck; Charles E Matthews Journal: Ann Epidemiol Date: 2011-07-07 Impact factor: 3.797
Authors: Christina M Pinkston; Richard N Baumgartner; Avonne E Connor; Stephanie D Boone; Kathy B Baumgartner Journal: J Cancer Surviv Date: 2015-03-05 Impact factor: 4.442
Authors: Cher M Dallal; Louise A Brinton; Charles E Matthews; Jolanta Lissowska; Beata Peplonska; Terryl J Hartman; Gretchen L Gierach Journal: Breast Cancer Res Treat Date: 2012-07-01 Impact factor: 4.872
Authors: Sarah S Cohen; Charles E Matthews; Patrick T Bradshaw; Loren Lipworth; Maciej S Buchowski; Lisa B Signorello; William J Blot Journal: Cancer Prev Res (Phila) Date: 2013-04-10