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Literature DB >> 20860920

Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity.

Abstract

Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating lipolysis in adipose tissue and fatty acid oxidation. Brown adipocyte development within white adipose tissue of humans suggests that mouse models may be applicable to human obesity. Consequently, new therapies should target adipose tissue to specifically reduce fat mass through controlled triglyceride utilization.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Triglycerides

Year: 2010 PMID： 20860920 PMCID： PMC2945394 DOI： 10.1016/j.coph.2010.05.008

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

54 in total

1. Cold-activated brown adipose tissue in healthy men.

Authors: Wouter D van Marken Lichtenbelt; Joost W Vanhommerig; Nanda M Smulders; Jamie M A F L Drossaerts; Gerrit J Kemerink; Nicole D Bouvy; Patrick Schrauwen; G J Jaap Teule
Journal: N Engl J Med Date: 2009-04-09 Impact factor: 91.245

2. Identification and importance of brown adipose tissue in adult humans.

Authors: Aaron M Cypess; Sanaz Lehman; Gethin Williams; Ilan Tal; Dean Rodman; Allison B Goldfine; Frank C Kuo; Edwin L Palmer; Yu-Hua Tseng; Alessandro Doria; Gerald M Kolodny; C Ronald Kahn
Journal: N Engl J Med Date: 2009-04-09 Impact factor: 91.245

3. Functional brown adipose tissue in healthy adults.

Authors: Kirsi A Virtanen; Martin E Lidell; Janne Orava; Mikael Heglind; Rickard Westergren; Tarja Niemi; Markku Taittonen; Jukka Laine; Nina-Johanna Savisto; Sven Enerbäck; Pirjo Nuutila
Journal: N Engl J Med Date: 2009-04-09 Impact factor: 91.245

4. Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism.

Authors: Dongning Pan; Masaki Fujimoto; Andrea Lopes; Yong-Xu Wang
Journal: Cell Date: 2009-04-03 Impact factor: 41.582

5. Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes.

Authors: Véronic Bezaire; Aline Mairal; Carole Ribet; Corinne Lefort; Amandine Girousse; Johan Jocken; Jurga Laurencikiene; Rodica Anesia; Anne-Marie Rodriguez; Mikael Ryden; Britta M Stenson; Christian Dani; Gérard Ailhaud; Peter Arner; Dominique Langin
Journal: J Biol Chem Date: 2009-05-11 Impact factor: 5.157

6. Perilipin A and the control of triacylglycerol metabolism.

Authors: Dawn L Brasaemle; Vidya Subramanian; Anne Garcia; Amy Marcinkiewicz; Alexis Rothenberg
Journal: Mol Cell Biochem Date: 2008-12-31 Impact factor: 3.396

Review 7. Transcriptional control of brown adipocyte development and physiological function--of mice and men.

Authors: Patrick Seale; Shingo Kajimura; Bruce M Spiegelman
Journal: Genes Dev Date: 2009-04-01 Impact factor: 11.361

8. Autophagy regulates lipid metabolism.

Authors: Rajat Singh; Susmita Kaushik; Yongjun Wang; Youqing Xiang; Inna Novak; Masaaki Komatsu; Keiji Tanaka; Ana Maria Cuervo; Mark J Czaja
Journal: Nature Date: 2009-04-01 Impact factor: 49.962

9. Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.

Authors: Maryam Ahmadian; Robin E Duncan; Krista A Varady; Danubia Frasson; Marc K Hellerstein; Andreas L Birkenfeld; Varman T Samuel; Gerald I Shulman; Yuhui Wang; Chulho Kang; Hei Sook Sul
Journal: Diabetes Date: 2009-01-09 Impact factor: 9.461

10. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.

Authors: Masayuki Saito; Yuko Okamatsu-Ogura; Mami Matsushita; Kumiko Watanabe; Takeshi Yoneshiro; Junko Nio-Kobayashi; Toshihiko Iwanaga; Masao Miyagawa; Toshimitsu Kameya; Kunihiro Nakada; Yuko Kawai; Masayuki Tsujisaki
Journal: Diabetes Date: 2009-04-28 Impact factor: 9.461

17 in total

1. Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice.

Authors: Genevieve Marcelin; Shun-Mei Liu; Xiaosong Li; Gary J Schwartz; Streamson Chua
Journal: J Lipid Res Date: 2012-03-01 Impact factor: 5.922

Review 2. An eicosanoid-centric view of atherothrombotic risk factors.

Authors: Scott Gleim; Jeremiah Stitham; Wai Ho Tang; Kathleen A Martin; John Hwa
Journal: Cell Mol Life Sci Date: 2012-04-11 Impact factor: 9.261

3. Fasting rapidly increases fatty acid oxidation in white adipose tissue of young broiler chickens.

Authors: Emmanuelle Torchon; Rodney Ray; Matthew W Hulver; Ryan P McMillan; Brynn H Voy
Journal: Adipocyte Date: 2016-12-07 Impact factor: 4.534

4. Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis.

Authors: Maria Szkudlarek-Mikho; Rudel A Saunders; Sook Fan Yap; Yun Fong Ngeow; Khew-Voon Chin
Journal: Biochem Biophys Res Commun Date: 2012-10-31 Impact factor: 3.575

Review 5. Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis.

Authors: Geneviève Marcelin; Ana Letícia M Silveira; Laís Bhering Martins; Adaliene Vm Ferreira; Karine Clément
Journal: J Clin Invest Date: 2019-10-01 Impact factor: 14.808

6. Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues.

Authors: Zhaobin Xu; Xiaohua Xu; Mianhua Zhong; Ian P Hotchkiss; Ryan P Lewandowski; James G Wagner; Lori A Bramble; Yifeng Yang; Aixia Wang; Jack R Harkema; Morton Lippmann; Sanjay Rajagopalan; Lung-Chi Chen; Qinghua Sun
Journal: Part Fibre Toxicol Date: 2011-07-11 Impact factor: 9.400

7. 5-aminolevulinic acid combined with ferrous ion reduces adiposity and improves glucose tolerance in diet-induced obese mice via enhancing mitochondrial function.

Authors: Urara Ota; Takeshi Hara; Hitoshi Nakagawa; Emi Tsuru; Masayuki Tsuda; Atsuko Kamiya; Yasushi Kuroda; Yuya Kitajima; Aya Koda; Masahiro Ishizuka; Hideo Fukuhara; Keiji Inoue; Taro Shuin; Motowo Nakajima; Tohru Tanaka
Journal: BMC Pharmacol Toxicol Date: 2017-01-30 Impact factor: 2.483