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Literature DB >> 20855745

LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.

Jody L Floyd¹, Kenneth P Smith, Sanath H Kumar, Jared T Floyd, Manuel F Varela.

Abstract

A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold, was observed for linezolid and tetraphenylphosphonium chloride (TPCL), followed by an 8-fold increase for sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. LmrS has 14 predicted membrane-spanning domains and is homologous to putative lincomycin resistance proteins of Bacillus spp., Lactobacillus spp., and Listeria spp.

Entities: Chemical Species

Mesh：

Substances：

Year: 2010 PMID： 20855745 PMCID： PMC2981259 DOI： 10.1128/AAC.00580-10

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

47 in total

1. Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system.

Authors: B Fournier; R Aras; D C Hooper
Journal: J Bacteriol Date: 2000-02 Impact factor: 3.490

Review 2. Molecular properties of bacterial multidrug transporters.

Authors: M Putman; H W van Veen; W N Konings
Journal: Microbiol Mol Biol Rev Date: 2000-12 Impact factor: 11.056

3. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins.

Authors: D A Rouch; D S Cram; D DiBerardino; T G Littlejohn; R A Skurray
Journal: Mol Microbiol Date: 1990-12 Impact factor: 3.501

4. Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.

Authors: J R Aires; T Köhler; H Nikaido; P Plésiat
Journal: Antimicrob Agents Chemother Date: 1999-11 Impact factor: 5.191

5. Characterization of P55, a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis.

Authors: P E Silva; F Bigi; M P Santangelo; M I Romano; C Martín; A Cataldi; J A Aínsa
Journal: Antimicrob Agents Chemother Date: 2001-03 Impact factor: 5.191

6. A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates.

Authors: Alexander J O'Neill; Anders R Larsen; Anne S Henriksen; Ian Chopra
Journal: Antimicrob Agents Chemother Date: 2004-09 Impact factor: 5.191

7. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome.

Authors: E Y Ng; M Trucksis; D C Hooper
Journal: Antimicrob Agents Chemother Date: 1994-06 Impact factor: 5.191

8. Emr, an Escherichia coli locus for multidrug resistance.

Authors: O Lomovskaya; K Lewis
Journal: Proc Natl Acad Sci U S A Date: 1992-10-01 Impact factor: 11.205

9. Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.

Authors: J M Tennent; B R Lyon; M Midgley; I G Jones; A S Purewal; R A Skurray
Journal: J Gen Microbiol Date: 1989-01

10. Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB.

Authors: H Furukawa; J T Tsay; S Jackowski; Y Takamura; C O Rock
Journal: J Bacteriol Date: 1993-06 Impact factor: 3.490

45 in total

10. Stress Resistance and Pathogenicity of Nonthermal-Plasma-Induced Viable-but-Nonculturable Staphylococcus aureus through Energy Suppression, Oxidative Stress Defense, and Immune-Escape Mechanisms.

Authors: Xinyu Liao; Weicheng Hu; Donghong Liu; Tian Ding
Journal: Appl Environ Microbiol Date: 2021-01-04 Impact factor: 4.792

LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.

1. Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system.

Review 2. Molecular properties of bacterial multidrug transporters.

3. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins.

4. Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.

5. Characterization of P55, a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis.

6. A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates.

7. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome.

8. Emr, an Escherichia coli locus for multidrug resistance.

9. Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.

10. Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB.

Review 1. Resistance to linezolid caused by modifications at its binding site on the ribosome.

2. Analyses of multidrug efflux pump-like proteins encoded on the Staphylococcus aureus chromosome.

Review 3. Molecular mechanisms of antibiotic resistance.

4. Transcriptional Regulator TetR21 Controls the Expression of the Staphylococcus aureus LmrS Efflux Pump.

Review 5. Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

Review 6. Emergence of antibiotic-resistant extremophiles (AREs).

Review 7. Multidrug efflux pumps in Staphylococcus aureus and their clinical implications.

Review 8. Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions.

Review 9. Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.

10. Stress Resistance and Pathogenicity of Nonthermal-Plasma-Induced Viable-but-Nonculturable Staphylococcus aureus through Energy Suppression, Oxidative Stress Defense, and Immune-Escape Mechanisms.