Literature DB >> 28584148

Transcriptional Regulator TetR21 Controls the Expression of the Staphylococcus aureus LmrS Efflux Pump.

Q C Truong-Bolduc1, Y Wang1, C Chen1, D C Hooper2.   

Abstract

TetR21 controls the expression of Tet38 and LmrS efflux pumps. A tetR21 mutant, QT21, exhibited a 4-fold increase in the transcription level of lmrSStaphylococcus aureuslmrS overexpressor showed increases of 4-fold and 2-fold, respectively, in the MICs of chloramphenicol and erythromycin, while the MICs of lmrS mutant QT18 and lmrS-tetR21 mutant QT1821 remained similar to those of parental strain RN6390. TetR21 does not bind to the promoter of lmrS, suggesting indirect regulation of lmrS.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  LmrS; S. aureus; TetR21; antibiotics; transporter

Mesh：

Substances：

Year:  2017        PMID： 28584148      PMCID： PMC5527640          DOI： 10.1128/AAC.00649-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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Authors:  Q C Truong-Bolduc; P M Dunman; J Strahilevitz; S J Projan; D C Hooper
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Journal:  J Bacteriol       Date:  2003-05       Impact factor: 3.490

7.  Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.

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2.  Tet38 of Staphylococcus aureus Binds to Host Cell Receptor Complex CD36-Toll-Like Receptor 2 and Protects from Teichoic Acid Synthesis Inhibitors Tunicamycin and Congo Red.

Authors:  Q C Truong-Bolduc; Y Wang; D C Hooper
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3.  Role of Staphylococcus aureus Tet38 in Transport of Tetracycline and Its Regulation in a Salt Stress Environment.

Authors:  Q C Truong-Bolduc; Y Wang; D C Hooper
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4.  Phenotypic Plasticity of Staphylococcus aureus in Liquid Medium Containing Vancomycin.

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