Literature DB >> 20854789

Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin.

Satish K Nair1, Wilfred A van der Donk.   

Abstract

Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20854789      PMCID： PMC3040005          DOI： 10.1016/j.abb.2010.09.012

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  46 in total

Review 1.  Bioactive natural products with carbon-phosphorus bonds and their biosynthesis.

Authors:  H Seto; T Kuzuyama
Journal:  Nat Prod Rep       Date:  1999-10       Impact factor: 13.423

2.  Protein purification and function assignment of the epoxidase catalyzing the formation of fosfomycin.

Authors:  P Liu; K Murakami; T Seki; X He; S M Yeung; T Kuzuyama; H Seto; H Liu
Journal:  J Am Chem Soc       Date:  2001-05-16       Impact factor: 15.419

3.  Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate.

Authors:  Zongbao Zhao; Pinghua Liu; Kazuo Murakami; Tomohisa Kuzuyama; Haruo Seto; Hung-wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2002-12-02       Impact factor: 15.336

4.  Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633.

Authors:  Svetlana A Borisova; Benjamin T Circello; Jun Kai Zhang; Wilfred A van der Donk; William W Metcalf
Journal:  Chem Biol       Date:  2010-01-29

5.  Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+).

Authors:  Chris L Rife; Rachel E Pharris; Marcia E Newcomer; Richard N Armstrong
Journal:  J Am Chem Soc       Date:  2002-09-18       Impact factor: 15.419

Review 6.  Biosynthesis of phosphonic and phosphinic acid natural products.

Authors:  William W Metcalf; Wilfred A van der Donk
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643

7.  Structure of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway for phosphonate degradation.

Authors:  Kateryna Podzelinska; Shu-Mei He; Matthew Wathier; Alexander Yakunin; Michael Proudfoot; Bjarne Hove-Jensen; David L Zechel; Zongchao Jia
Journal:  J Biol Chem       Date:  2009-04-14       Impact factor: 5.157

8.  An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis.

Authors:  Robert M Cicchillo; Houjin Zhang; Joshua A V Blodgett; John T Whitteck; Gongyong Li; Satish K Nair; Wilfred A van der Donk; William W Metcalf
Journal:  Nature       Date:  2009-06-11       Impact factor: 49.962

Review 9.  Follow the leader: the use of leader peptides to guide natural product biosynthesis.

Authors:  Trent J Oman; Wilfred A van der Donk
Journal:  Nat Chem Biol       Date:  2010-01       Impact factor: 15.040

10.  Hydroperoxylation by hydroxyethylphosphonate dioxygenase.

Authors:  John T Whitteck; Robert M Cicchillo; Wilfred A van der Donk
Journal:  J Am Chem Soc       Date:  2009-11-11       Impact factor: 15.419
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  8 in total

1.  The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase.

Authors:  Mark F Mabanglo; Adrian W R Serohijos; C Dale Poulter
Journal:  Biochemistry       Date:  2012-01-11       Impact factor: 3.162

Review 2.  Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases.

Authors:  Salette Martinez; Robert P Hausinger
Journal:  J Biol Chem       Date:  2015-07-07       Impact factor: 5.157

3.  Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

Authors:  Philip Olivares; Emily C Ulrich; Jonathan R Chekan; Wilfred A van der Donk; Satish K Nair
Journal:  ACS Chem Biol       Date:  2016-12-27       Impact factor: 5.100

4.  Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase.

Authors:  Alexander Kim; Matthew M Benning; Sang OkLee; John Quinn; Brian M Martin; Hazel M Holden; Debra Dunaway-Mariano
Journal:  Biochemistry       Date:  2011-04-08       Impact factor: 3.162

5.  GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme.

Authors:  Hak Joong Kim; Reid M McCarty; Yasushi Ogasawara; Yung-nan Liu; Steven O Mansoorabadi; Jake LeVieux; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2013-05-21       Impact factor: 15.419

6.  Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation.

Authors:  Vinayak Agarwal; Spencer C Peck; Jui-Hui Chen; Svetlana A Borisova; Jonathan R Chekan; Wilfred A van der Donk; Satish K Nair
Journal:  Chem Biol       Date:  2013-12-19

Review 7.  Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology.

Authors:  Spencer C Peck; Wilfred A van der Donk
Journal:  Curr Opin Chem Biol       Date:  2013-07-17       Impact factor: 8.822

8.  Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean.

Authors:  William W Metcalf; Benjamin M Griffin; Robert M Cicchillo; Jiangtao Gao; Sarath Chandra Janga; Heather A Cooke; Benjamin T Circello; Bradley S Evans; Willm Martens-Habbena; David A Stahl; Wilfred A van der Donk
Journal:  Science       Date:  2012-08-31       Impact factor: 47.728
  8 in total

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