Satish K Nair1, Wilfred A van der Donk. 1. Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA.
Abstract
Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.
Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. Tpan class="Chemical">his review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.
Authors: Robert M Cicchillo; Houjin Zhang; Joshua A V Blodgett; John T Whitteck; Gongyong Li; Satish K Nair; Wilfred A van der Donk; William W Metcalf Journal: Nature Date: 2009-06-11 Impact factor: 49.962
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Authors: Alexander Kim; Matthew M Benning; Sang OkLee; John Quinn; Brian M Martin; Hazel M Holden; Debra Dunaway-Mariano Journal: Biochemistry Date: 2011-04-08 Impact factor: 3.162
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Authors: Vinayak Agarwal; Spencer C Peck; Jui-Hui Chen; Svetlana A Borisova; Jonathan R Chekan; Wilfred A van der Donk; Satish K Nair Journal: Chem Biol Date: 2013-12-19
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