Literature DB >> 2082833

The effects of scleroderma sera on endothelial cell survival in vitro.

T Etoh1, A Igarashi, K Iozumi, Y Ishibashi, K Takehara.   

Abstract

The effects of sera and of platelet-poor plasma from patients with scleroderma on endothelial cell survival in vitro were studied. The survival ratio of rat heart endothelial cells was studied both in 10% test serum and in 10% platelet-poor plasma. Sera from patients with scleroderma decreased the survival ratio significantly when compared with sera from normal controls. In contrast, there was no significant difference between platelet-poor plasma from patients with scleroderma and that from normal controls. Our data indicate that platelets in the patients with scleroderma may cause vascular damage by affecting endothelial cell survival.

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Year:  1990        PMID： 2082833     DOI： 10.1007/BF00371946

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  24 in total

1.  The effects of various growth factors on endothelial cell survival in vitro.

Authors:  T Etoh; K Takehara; A Igarashi; Y Ishibashi
Journal:  Biochem Biophys Res Commun       Date:  1989-08-15       Impact factor: 3.575

2.  Mitogenic activities for skin fibroblasts in the sera from untreated scleroderma patients at the early stage.

Authors:  A Igarashi; K Takehara; Y Soma; K Kikuchi; Y Ishibashi
Journal:  Arch Dermatol Res       Date:  1989       Impact factor: 3.017

3.  Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

Authors:  M D O'Connor-McCourt; L M Wakefield
Journal:  J Biol Chem       Date:  1987-10-15       Impact factor: 5.157

4.  Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

Authors:  R A Ignotz; J Massagué
Journal:  J Biol Chem       Date:  1986-03-25       Impact factor: 5.157

5.  A platelet factor that stimulates the proliferation of vascular endothelial cells.

Authors:  K Miyazono; T Okabe; A Urabe; M Yamanaka; F Takaku
Journal:  Biochem Biophys Res Commun       Date:  1985-01-16       Impact factor: 3.575

6.  The effects of scleroderma serum on human microvascular endothelial cells. Induction of antibody-dependent cellular cytotoxicity.

Authors:  R M Marks; M Czerniecki; B S Andrews; R Penny
Journal:  Arthritis Rheum       Date:  1988-12

7.  Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.

Authors:  Y Oka; D N Orth
Journal:  J Clin Invest       Date:  1983-07       Impact factor: 14.808

8.  Autoantibody to centromere (kinetochore) in scleroderma sera.

Authors:  Y Moroi; C Peebles; M J Fritzler; J Steigerwald; E M Tan
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

Review 9.  Vascular disease in progressive systemic sclerosis (scleroderma).

Authors:  W L Norton; J M Nardo
Journal:  Ann Intern Med       Date:  1970-08       Impact factor: 25.391

10.  Transforming growth factor-beta: selective increase in glycosaminoglycan synthesis by cultures of fibroblasts from patients with progressive systemic sclerosis.

Authors:  V Falanga; S L Tiegs; S P Alstadt; A B Roberts; M B Sporn
Journal:  J Invest Dermatol       Date:  1987-07       Impact factor: 8.551
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  2 in total

1.  Response of scleroderma fibroblasts to various growth factors.

Authors:  K Takehara; Y Soma; A Igarashi; K Kikuchi; A Moro; Y Ishibashi
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

2.  Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension.

Authors:  S A Kharitonov; J B Cailes; C M Black; R M du Bois; P J Barnes
Journal:  Thorax       Date:  1997-12       Impact factor: 9.139
  2 in total

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