Literature DB >> 6966403

Autoantibody to centromere (kinetochore) in scleroderma sera.

Y Moroi, C Peebles, M J Fritzler, J Steigerwald, E M Tan.   

Abstract

Sera from patients with scleroderma contained several autoantibodies to nuclear antigens which were distinguished by different patterns of nuclear immunofluorescence staining. One of these autoantibodies reacted with centromeric regions of chromosomes. In chromosome spreads, the staining appeared as two small spheres at the centromere, resembling kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly bound to DNA. The autoantibody was reactive with centromeres of cells derived from humans, mice, and Chinese hamsters. The autoantibody was present in high frequency in the calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma.

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Year:  1980        PMID： 6966403      PMCID： PMC348550          DOI： 10.1073/pnas.77.3.1627

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Combined titre and fluorescent pattern of IgG antinuclear antibodies using cultured cell monolayers in evaluating connective tissue diseases.

Authors:  M D Parker; G P Kerby
Journal:  Ann Rheum Dis       Date:  1974-09       Impact factor: 19.103

2.  The immunofluorescent tumor imprint technique. II. The frequency of antinuclear factors in connective tissue diseases and dermatoses.

Authors:  T K Burnham; G Fine; T R Neblett
Journal:  Ann Intern Med       Date:  1966-07       Impact factor: 25.391

3.  Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines.

Authors:  B M Reedman; G Klein
Journal:  Int J Cancer       Date:  1973-05       Impact factor: 7.396

4.  New selective Giemsa technique for human chromosomes, Cd staining.

Authors:  H Eiberg
Journal:  Nature       Date:  1974-03-01       Impact factor: 49.962

5.  An immunological study of the fates of nuclear and nucleolar macromoleculus during the cell cycle.

Authors:  E M Tan; R A Lerner
Journal:  J Mol Biol       Date:  1972-07-14       Impact factor: 5.469

6.  Antinucleolar antibodies in human sera.

Authors:  J L Pinnas; J D Northway; E M Tan
Journal:  J Immunol       Date:  1973-10       Impact factor: 5.422

7.  Dissection of chromosome structure with trypsin and nucleases.

Authors:  H Weintraub; F Van Lente
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

8.  Relationship of nuclear staining patterns with precipitating antibodies in systemic lupus erythematosus.

Authors:  E M Tan
Journal:  J Lab Clin Med       Date:  1967-11

9.  Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus.

Authors:  E M Tan; H G Kunkel
Journal:  J Immunol       Date:  1966-03       Impact factor: 5.422

10.  Serum antinuclear antibodies in progressive systemic sclerosis (scleroderma).

Authors:  N F Rothfield; G P Rodnan
Journal:  Arthritis Rheum       Date:  1968-10
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  229 in total

1.  1st International Conference on the Mammalian Centromere. Taichung, Taiwan, 2-4 October 1998. Abstracts.

Authors: 
Journal:  Chromosome Res       Date:  1998-12       Impact factor: 5.239

2.  Visualization of prekinetochore locus on the centromeric region of highly extended chromatin fibers: does kinetochore autoantigen CENP-C constitute a kinetochore organizing center?

Authors:  K Sugimoto; M Tsutsui; D AuCoin; B K Vig
Journal:  Chromosome Res       Date:  1999       Impact factor: 5.239

3.  CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells.

Authors:  T Fukagawa; Y Mikami; A Nishihashi; V Regnier; T Haraguchi; Y Hiraoka; N Sugata; K Todokoro; W Brown; T Ikemura
Journal:  EMBO J       Date:  2001-08-15       Impact factor: 11.598

4.  Creation and characterization of temperature-sensitive CENP-C mutants in vertebrate cells.

Authors:  T Fukagawa; V Regnier; T Ikemura
Journal:  Nucleic Acids Res       Date:  2001-09-15       Impact factor: 16.971

5.  Cell cycle-dependent expression and nucleolar localization of hCAP-H.

Authors:  O A Cabello; E Eliseeva; W G He; H Youssoufian; S E Plon; B R Brinkley; J W Belmont
Journal:  Mol Biol Cell       Date:  2001-11       Impact factor: 4.138

6.  Anti-topoisomerase II alpha autoantibodies in systemic sclerosis-association with pulmonary hypertension and HLA-B35.

Authors:  B Grigolo; I Mazzetti; R Meliconi; S Bazzi; R Scorza; M Candela; A Gabrielli; A Facchini
Journal:  Clin Exp Immunol       Date:  2000-09       Impact factor: 4.330

7.  A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation.

Authors:  F R Bischoff; G Maier; G Tilz; H Ponstingl
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

8.  Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

Authors:  K Xie; M Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

9.  Human anti-centromere sera recognise a 19.5 kD non-histone chromosomal protein from HeLa cells.

Authors:  H H Guldner; H J Lakomek; F A Bautz
Journal:  Clin Exp Immunol       Date:  1984-10       Impact factor: 4.330

10.  Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera.

Authors:  M Satoh; A K Ajmani; T Ogasawara; J J Langdon; M Hirakata; J Wang; W H Reeves
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808
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