Literature DB >> 2848531

The effects of scleroderma serum on human microvascular endothelial cells. Induction of antibody-dependent cellular cytotoxicity.

R M Marks1, M Czerniecki, B S Andrews, R Penny.   

Abstract

To investigate the vascular immunopathology of systemic sclerosis, we developed a model consisting of human microvascular endothelial cells, leukocytes, and serum. Sera from 19% of the patients studied mediated antibody-dependent cellular cytotoxicity against endothelial cells. Some sera also mediated cytotoxicity against aortic endothelium and fibroblasts. K lymphocytes, the cells that mediate antibody-dependent cellular cytotoxicity, were identified in the skin of some patients. The sera alone were not cytotoxic or growth inhibitory, and did not affect endothelial prostacyclin production.

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Year:  1988        PMID： 2848531     DOI： 10.1002/art.1780311209

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  11 in total

Review 1.  Anti-endothelial cell antibodies in systemic sclerosis.

Authors:  Y Renaudineau; R Revelen; Y Levy; K Salojin; B Gilburg; Y Shoenfeld; P Youinou
Journal:  Clin Diagn Lab Immunol       Date:  1999-03

2.  The effects of scleroderma sera on endothelial cell survival in vitro.

Authors:  T Etoh; A Igarashi; K Iozumi; Y Ishibashi; K Takehara
Journal:  Arch Dermatol Res       Date:  1990       Impact factor: 3.017

Review 3.  Rheumatology.

Authors:  R A Asherson; R Cervera; D P D'Cruz; G R Hughes
Journal:  Postgrad Med J       Date:  1991-02       Impact factor: 2.401

4.  Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma.

Authors:  R Sgonc; M S Gruschwitz; H Dietrich; H Recheis; M E Gershwin; G Wick
Journal:  J Clin Invest       Date:  1996-08-01       Impact factor: 14.808

5.  Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies.

Authors:  C O Savage; B E Pottinger; G Gaskin; C M Lockwood; C D Pusey; J D Pearson
Journal:  Clin Exp Immunol       Date:  1991-07       Impact factor: 4.330

Review 6.  The endothelium: its role in scleroderma.

Authors:  J D Pearson
Journal:  Ann Rheum Dis       Date:  1991-11       Impact factor: 19.103

7.  Assessment of anti-endothelial cell antibodies in systemic sclerosis and Sjögren's syndrome.

Authors:  M Hebbar; P Lassalle; Y Delneste; P Y Hatron; B Devulder; A B Tonnel; A Janin
Journal:  Ann Rheum Dis       Date:  1997-04       Impact factor: 19.103

8.  Antibody-dependent cellular cytotoxicity of vascular endothelium: characterization and pathogenic associations in systemic sclerosis.

Authors:  C M Holt; N Lindsey; J Moult; R G Malia; M Greaves; A Hume; N R Rowell; P Hughes
Journal:  Clin Exp Immunol       Date:  1989-12       Impact factor: 4.330

9.  IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines.

Authors:  D Carvalho; C O Savage; C M Black; J D Pearson
Journal:  J Clin Invest       Date:  1996-01-01       Impact factor: 14.808

Review 10.  Vascular disease in scleroderma.

Authors:  Fredrick M Wigley
Journal:  Clin Rev Allergy Immunol       Date:  2009-06       Impact factor: 8.667
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