Literature DB >> 208152

Chemical evolution from hydrogen cyanide: photochemical decarboxylation of orotic acid and orotate derivatives.

J P Ferris, P C Joshi.   

Abstract

Irradiation of solutions at pH 7 to pH 8.5 of orotic acid, orotidine, and orotidine 5'-phosphate with light at 254 nanometers yields the corresponding uracil derivative via the singlet excited state. This reaction completes a plausible prebiotic synthesis of uracil and its derivatives starting from HCN as the only carbon source.

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Year:  1978        PMID： 208152     DOI： 10.1126/science.208152

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

1.  The cold origin of life: B. Implications based on pyrimidines and purines produced from frozen ammonium cyanide solutions.

Authors:  Shin Miyakawa; H James Cleaves; Stanley L Miller
Journal:  Orig Life Evol Biosph       Date:  2002-06       Impact factor: 1.950

2.  Orotidine-Containing RNA: Implications for the Hierarchical Selection (Systems Chemistry Emergence) of RNA.

Authors:  Eun-Kyong Kim; Vincent Martin; Ramanarayanan Krishnamurthy
Journal:  Chemistry       Date:  2017-08-11       Impact factor: 5.236

3.  Primeval procreative comet pond.

Authors:  B C Clark
Journal:  Orig Life Evol Biosph       Date:  1988       Impact factor: 1.950

4.  Prebiotic synthesis of orotic acid parallel to the biosynthetic pathway.

Authors:  Y Yamagata; K Sasaki; O Takaoka; S Sano; K Inomata; K Kanemitsu; Y Inoue; I Matsumoto
Journal:  Orig Life Evol Biosph       Date:  1990       Impact factor: 1.950

5.  Organic syntheses from CH4-N2 atmospheres: implications for Titan.

Authors:  F Raulin; D Mourey; G Toupance
Journal:  Orig Life       Date:  1982-09
  5 in total

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