OBJECTIVE: We aimed to estimate the effective dose of 4D-Perfusion-CT protocols of the lung, liver, and pelvis for the assessment of tumor vascularity. MATERIALS AND METHODS: An Alderson-Rando phantom equipped with thermoluminescent dosimeters was used to determine the effective dose values of 4D-Perfusion-CT. Phantom measurements were performed on a 128-slice single-source scanner in adaptive 4D-spiral-mode with bidirectional table movement and a total scan range of 69 mm over a time period of nearly 120 seconds (26 scans). Perfusion measurements were simulated for the lung, liver, and pelvis under the following conditions: lung (80 kV, 60 mAs), liver (80 kV/80 mAs and 80 kV/120 mAs), pelvis (100 kV/80 mAs and 100 kV/120 mAs). RESULTS: Depending on gender, the evaluated body region and scan protocol, an effective whole-body dose between 2.9-12.2 mSv, was determined. The radiation exposure administered to gender-specific organs like the female breast tissue (lung perfusion) or to the ovaries (pelvic perfusion) led to an increase in the female specific dose by 86% and 100% in perfusion scans of the lung and the pelvis, respectively. CONCLUSION: Due to a significant radiation dose of 4D-perfusion-CT protocols, the responsible use of this new promising technique is mandatory. Gender- and organ-specific differences should be considered for indication and planning of tumor perfusion scans.
OBJECTIVE: We aimed to estimate the effective dose of 4D-Perfusion-CT protocols of the lung, liver, and pelvis for the assessment of tumor vascularity. MATERIALS AND METHODS: An Alderson-Rando phantom equipped with thermoluminescent dosimeters was used to determine the effective dose values of 4D-Perfusion-CT. Phantom measurements were performed on a 128-slice single-source scanner in adaptive 4D-spiral-mode with bidirectional table movement and a total scan range of 69 mm over a time period of nearly 120 seconds (26 scans). Perfusion measurements were simulated for the lung, liver, and pelvis under the following conditions: lung (80 kV, 60 mAs), liver (80 kV/80 mAs and 80 kV/120 mAs), pelvis (100 kV/80 mAs and 100 kV/120 mAs). RESULTS: Depending on gender, the evaluated body region and scan protocol, an effective whole-body dose between 2.9-12.2 mSv, was determined. The radiation exposure administered to gender-specific organs like the female breast tissue (lung perfusion) or to the ovaries (pelvic perfusion) led to an increase in the female specific dose by 86% and 100% in perfusion scans of the lung and the pelvis, respectively. CONCLUSION: Due to a significant radiation dose of 4D-perfusion-CT protocols, the responsible use of this new promising technique is mandatory. Gender- and organ-specific differences should be considered for indication and planning of tumor perfusion scans.
Authors: Dominik Ketelsen; Christoph Thomas; Matthias Werner; Marie H Luetkhoff; Markus Buchgeister; Ilias Tsiflikas; Anja Reimann; Christof Burgstahler; Harald Brodoefel; Andreas F Kopp; Claus D Claussen; Martin Heuschmid Journal: Eur J Radiol Date: 2008-12-18 Impact factor: 3.528
Authors: Sven Schneeweiß; Marius Horger; Anja Grözinger; Konstantin Nikolaou; Dominik Ketelsen; Roland Syha; Gerd Grözinger Journal: Cancer Imaging Date: 2016-12-15 Impact factor: 3.909
Authors: Daniel Spira; Matthias Wecker; Sven Michael Spira; Jürgen Hetzel; Werner Spengler; Alexander Sauter; Marius Horger Journal: Cancer Imaging Date: 2013-07-22 Impact factor: 3.909
Authors: Roland Syha; Sergios Gatidis; Gerd Grözinger; Ulrich Grosse; Michael Maurer; Lars Zender; Marius Horger; Konstantin Nikolaou; Dominik Ketelsen Journal: Cancer Imaging Date: 2016-09-21 Impact factor: 3.909