Literature DB >> 20805396

A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes.

Ritu Banerjee1, Michael Gretes, Christopher Harlem, Li Basuino, Henry F Chambers.   

Abstract

We previously generated a ceftobiprole-resistant Staphylococcus aureus strain after high inoculum serial passage of a mecA-negative variant of strain COL (R. Banerjee, M. Gretes, L. Basuino, N. Strynadka, and H. F. Chambers, Antimicrob. Agents Chemother. 52:2089-2096, 2008). Genome resequencing of this strain, CRB, revealed that it differs from its parent by five single-nucleotide polymorphisms in three genes, specifically, those encoding PBP4, a low-molecular-weight penicillin-binding protein, GdpP, a predicted signaling protein, and AcrB, a cation multidrug efflux transporter. CRB displayed resistance to a variety of β-lactams but was hypersusceptible to cefoxitin.

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Year:  2010        PMID： 20805396      PMCID： PMC2976154          DOI： 10.1128/AAC.00594-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

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Authors:  Stan Deresinski
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Journal:  Curr Opin Struct Biol       Date:  2008-08-09       Impact factor: 6.809

3.  Role of penicillin-binding protein 4 in expression of vancomycin resistance among clinical isolates of oxacillin-resistant Staphylococcus aureus.

Authors:  J E Finan; G L Archer; M J Pucci; M W Climo
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

4.  The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner.

Authors:  Fei Shang; Ting Xue; Haipeng Sun; Lei Xing; Shuo Zhang; Zhenjun Yang; Lihe Zhang; Baolin Sun
Journal:  Infect Immun       Date:  2009-04-20       Impact factor: 3.441

5.  Binding of ceftaroline to penicillin-binding proteins of Staphylococcus aureus and Streptococcus pneumoniae.

Authors:  Hélène Moisan; Mireille Pruneau; François Malouin
Journal:  J Antimicrob Chemother       Date:  2010-01-22       Impact factor: 5.790

6.  Jumping the barrier to beta-lactam resistance in Staphylococcus aureus.

Authors:  Yuki Katayama; Hong-Zhong Zhang; Dong Hong; Henry F Chambers
Journal:  J Bacteriol       Date:  2003-09       Impact factor: 3.490

7.  Molecular basis for the role of Staphylococcus aureus penicillin binding protein 4 in antimicrobial resistance.

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Journal:  J Bacteriol       Date:  2010-01       Impact factor: 3.490

8.  Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.

Authors:  Guido Memmi; Sergio R Filipe; Mariana G Pinho; Zhibiao Fu; Ambrose Cheung
Journal:  Antimicrob Agents Chemother       Date:  2008-08-25       Impact factor: 5.191

9.  Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureus.

Authors:  K Sieradzki; A Tomasz
Journal:  J Bacteriol       Date:  2003-12       Impact factor: 3.490

10.  Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy.

Authors:  Christopher A Elkins; Lisa B Mullis; David W Lacher; Carina M Jung
Journal:  Antimicrob Agents Chemother       Date:  2009-12-28       Impact factor: 5.191
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  48 in total

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Journal:  Antimicrob Agents Chemother       Date:  2011-06-02       Impact factor: 5.191

2.  Nuclease-Resistant c-di-AMP Derivatives That Differentially Recognize RNA and Protein Receptors.

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3.  The Second Messenger c-di-AMP Regulates Diverse Cellular Pathways Involved in Stress Response, Biofilm Formation, Cell Wall Homeostasis, SpeB Expression, and Virulence in Streptococcus pyogenes.

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Journal:  Infect Immun       Date:  2019-05-21       Impact factor: 3.441

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Authors:  G E Fosheim; A C Nicholson; V S Albrecht; B M Limbago
Journal:  J Clin Microbiol       Date:  2011-06-22       Impact factor: 5.948

5.  c-di-AMP-Regulated K+ Importer KtrAB Affects Biofilm Formation, Stress Response, and SpeB Expression in Streptococcus pyogenes.

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Review 6.  Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria.

Authors:  Fabian M Commichau; Jana L Heidemann; Ralf Ficner; Jörg Stülke
Journal:  J Bacteriol       Date:  2018-12-07       Impact factor: 3.490

7.  New role of the disulfide stress effector YjbH in β-lactam susceptibility of Staphylococcus aureus.

Authors:  Nadine Göhring; Iris Fedtke; Guoqing Xia; Ana M Jorge; Mariana G Pinho; Ute Bertsche; Andreas Peschel
Journal:  Antimicrob Agents Chemother       Date:  2011-09-26       Impact factor: 5.191

8.  Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence.

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9.  High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant Staphylococcus aureus Isolates from a Hospital in Central Italy.

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Journal:  Antimicrob Agents Chemother       Date:  2018-11-26       Impact factor: 5.191

10.  Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection.

Authors:  Jun Yang; Yinlan Bai; Yang Zhang; Vincent D Gabrielle; Lei Jin; Guangchun Bai
Journal:  Mol Microbiol       Date:  2014-05-23       Impact factor: 3.501
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