Literature DB >> 20805389

Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin.

Jun Okuda1, Naoki Hayashi, Yuka Wakahara, Naomasa Gotoh.   

Abstract

A mini-Tn5 insertion into a ciprofloxacin (CIP)-resistant mutant of Vibrio cholerae O1 revealed that overexpression of the vca0421 gene, which encodes a hypothetical protein, in the CIP-resistant mutant carrying a mutation in the quinolone resistance-determining region (QRDR) of the gyrA gene causes sensitization to CIP. We propose a new intrinsic mechanism of resistance to fluoroquinolones due to the inherently reduced expression of the vca0421 gene in V. cholerae O1.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20805389      PMCID： PMC2976169          DOI： 10.1128/AAC.01652-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Emergence of fluoroquinolone-resistant strains of Vibrio cholerae O1 biotype El Tor among hospitalized patients with cholera in Calcutta, India.

Authors:  P Garg; S Sinha; R Chakraborty; S K Bhattacharya; G B Nair; T Ramamurthy; Y Takeda
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

2.  Survey of in vitro susceptibilities of Vibrio cholerae O1 and O139 to antimicrobial agents.

Authors:  T Yamamoto; G B Nair; M J Albert; C C Parodi; Y Takeda
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

3.  Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase.

Authors:  S L Swanberg; J C Wang
Journal:  J Mol Biol       Date:  1987-10-20       Impact factor: 5.469

4.  DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy.

Authors:  T Adachi; M Mizuuchi; E A Robinson; E Appella; M H O'Dea; M Gellert; K Mizuuchi
Journal:  Nucleic Acids Res       Date:  1987-01-26       Impact factor: 16.971

5.  Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

Authors:  H Yoshida; M Bogaki; M Nakamura; S Nakamura
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

6.  Base changes in the fliC gene of Edwardsiella tarda: possible effects on flagellation and motility.

Authors:  Jun Okuda; Fumiyasu Murayama; Eisuke Yamanoi; Emi Iwamoto; Satoru Matsuoka; Mitsuaki Nishibuchi; Toshihiro Nakai
Journal:  Dis Aquat Organ       Date:  2007-06-29       Impact factor: 1.802

7.  Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.

Authors:  Somesh Baranwal; Keya Dey; T Ramamurthy; G Balakrish Nair; Manikuntala Kundu
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

8.  Manifestation of the Kanagawa phenomenon, the virulence-associated phenotype, of Vibrio parahaemolyticus depends on a particular single base change in the promoter of the thermostable direct haemolysin gene.

Authors:  J Okuda; M Nishibuchi
Journal:  Mol Microbiol       Date:  1998-11       Impact factor: 3.501

9.  Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions.

Authors:  H Peng; K J Marians
Journal:  J Biol Chem       Date:  1993-11-15       Impact factor: 5.157

10.  Nucleotide sequence of the thermostable direct hemolysin gene of Vibrio parahaemolyticus.

Authors:  M Nishibuchi; J B Kaper
Journal:  J Bacteriol       Date:  1985-05       Impact factor: 3.490
View more
  1 in total

Review 1.  Chemoprophylaxis in contacts of patients with cholera: systematic review and meta-analysis.

Authors:  Ludovic Reveiz; Evelina Chapman; Pilar Ramon-Pardo; Tracey Perez Koehlmoos; Luis Gabriel Cuervo; Sylvain Aldighieri; Amy Chambliss
Journal:  PLoS One       Date:  2011-11-15       Impact factor: 3.240
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.