Literature DB >> 207555

Chemical synthesis of a hexadecapeptide segment of ubiquitin that activates adenylate cyclase and induces lymphocytes to differentiate.

D H Schlesinger, G Goldstein, M P Scheid, M Bitensky.   

Abstract

A hexadecapeptide corresponding to positions 59--74 of ubiquitin was synthesized and purified. The peptide was characterized by its mobility in TLC and electrophoresis, amino acid sequence and composition, and molar rotation. The peptide possessed approximately 40% activity compared with native ubiquitin in each of 3 biological assays in vitro: a) thymocyte induction, b) B cell induction and c) elevation of intracellular cyclic AMP levels in sarcoma 180 cells.

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Year:  1978        PMID： 207555     DOI： 10.1007/bf01947269

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.

Authors:  D H Schlesinger; G Goldstein
Journal:  Nature       Date:  1975-05-29       Impact factor: 49.962

2.  Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

Authors:  G Goldstein; M Scheid; U Hammerling; D H Schlesinger; H D Niall; E A Boyse
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

3.  The NH2- and COOH-terminal amino acid sequence of nuclear protein A24.

Authors:  M O Olson; I L Goldknopf; K A Guetzow; G T James; T C Hawkins; C J Mays-Rothberg; H Busch
Journal:  J Biol Chem       Date:  1976-10-10       Impact factor: 5.157

4.  In-vitro demonstration of thymic hormone in the mouse by conversion of precursor cells into lymphocytes.

Authors:  K Komuro; E A Boyse
Journal:  Lancet       Date:  1973-04-07       Impact factor: 79.321

5.  Solid-phase synthesis of the biologically active N-terminal 1 - 34 peptide of human parathyroid hormone.

Authors:  G W Tregear; J van Rietschoten; E Greene; H D Niall; H T Keutmann; J A Parsons; J L O'Riordan; J T Potts
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1974-04

6.  Analysis of amino acid phenylthiohydantoins by gas chromatography.

Authors:  J J Pisano; T J Bronzert
Journal:  J Biol Chem       Date:  1969-10-25       Impact factor: 5.157

7.  Isolation and chemical properties of two calcitonins from salmon ultimobranchial glands.

Authors:  H T Keutmann; J A Parsons; J T Potts; R J Schlueter
Journal:  J Biol Chem       Date:  1970-03-25       Impact factor: 5.157

8.  Chemical synthesis of a peptide fragment of thymopoietin II that induces selective T cell differentiation.

Authors:  D H Schlesinger; G Goldstein; M P Scheid; E A Boyse
Journal:  Cell       Date:  1975-08       Impact factor: 41.582

9.  The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells.

Authors:  D H Schlesinger; G Goldstein; H D Niall
Journal:  Biochemistry       Date:  1975-05-20       Impact factor: 3.162

10.  Thymopoietin and myasthenia gravis: neostigmine-responsive neuromuscular block produced in mice by a synthetic peptide fragment of thymopoietin.

Authors:  G Goldstein; D H Schlesinger
Journal:  Lancet       Date:  1975-08-09       Impact factor: 79.321
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  2 in total

1.  Ubiquitin - protein conjugates.

Authors:  H Busch; I L Goldknopf
Journal:  Mol Cell Biochem       Date:  1981-11-13       Impact factor: 3.396

2.  Immunoregulatory properties of ISG15, an interferon-induced cytokine.

Authors:  J D'Cunha; E Knight; A L Haas; R L Truitt; E C Borden
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205
  2 in total

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