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Literature DB >> 20740032

Handling accumulated internal Cl- at inhibitory synapses.

Abstract

A study in this issue finds that under conditions of intense activity at specific inhibitory synapses, the voltage gated Cl- channel CIC-2 is vital for allowing efflux of accumulated internal Cl-.

Entities: Gene

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Year: 2010 PMID： 20740032 DOI： 10.1038/nn0910-1043

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

15 in total

1. GABA action in immature neocortical neurons directly depends on the availability of ketone bodies.

Authors: Sylvain Rheims; Carl D Holmgren; Genevieve Chazal; Jan Mulder; Tibor Harkany; Tanya Zilberter; Yuri Zilberter
Journal: J Neurochem Date: 2009-06-22 Impact factor: 5.372

Review 2. Perisomatic inhibition.

Authors: Tamás F Freund; István Katona
Journal: Neuron Date: 2007-10-04 Impact factor: 17.173

3. The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.

Authors: C Rivera; J Voipio; J A Payne; E Ruusuvuori; H Lahtinen; K Lamsa; U Pirvola; M Saarma; K Kaila
Journal: Nature Date: 1999-01-21 Impact factor: 49.962

4. Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition.

Authors: R L Smith; G H Clayton; C L Wilcox; K W Escudero; K J Staley
Journal: J Neurosci Date: 1995-05 Impact factor: 6.167

Handling accumulated internal Cl- at inhibitory synapses.

1. GABA action in immature neocortical neurons directly depends on the availability of ketone bodies.

Review 2. Perisomatic inhibition.

3. The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.

4. Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition.

Review 5. Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models.

6. Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel.

7. Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.

Review 8. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations.

Review 9. CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.

10. Intracellular chloride ions regulate the time course of GABA-mediated inhibitory synaptic transmission.

1. Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel.