| Literature DB >> 17920013 |
Tamás F Freund1, István Katona.
Abstract
Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.Entities:
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Year: 2007 PMID： 17920013 DOI： 10.1016/j.neuron.2007.09.012
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173