Literature DB >> 7751965

Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition.

R L Smith1, G H Clayton, C L Wilcox, K W Escudero, K J Staley.   

Abstract

A voltage-sensitive inwardly rectifying chloride (Cl-) conductance (GCl(V) is present in hippocampal pyramidal but not dentate gyrus neurons and has a significant role in modulation of neuronal inhibition by GABA. GCl(V) has the same activation properties as the cloned and expressed Cl- channel CIC-2. In brain, CIC-2 was detected selectively in neurons, and in hippocampus was detected in the same populations of neurons that demonstrate GCl(V). CIC-2 mRNA expression varied widely in different neuronal populations in brain but was greatest in pyramidal and other large neurons and least in interneurons. The observed differential expression of CIC-2 provides a potential molecular basis for the paradoxical excitation produced by GABAA receptor activation in selected neuronal populations.

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Year:  1995        PMID： 7751965      PMCID： PMC6578181     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  45 in total

1.  A furosemide-sensitive K+-Cl- cotransporter counteracts intracellular Cl- accumulation and depletion in cultured rat midbrain neurons.

Authors:  W Jarolimek; A Lewen; U Misgeld
Journal:  J Neurosci       Date:  1999-06-15       Impact factor: 6.167

2.  Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.

Authors:  M R Bösl; V Stein; C Hübner; A A Zdebik; S E Jordt; A K Mukhopadhyay; M S Davidoff; A F Holstein; T J Jentsch
Journal:  EMBO J       Date:  2001-03-15       Impact factor: 11.598

3.  Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport.

Authors:  K J Staley; W R Proctor
Journal:  J Physiol       Date:  1999-09-15       Impact factor: 5.182

4.  Evidence that different cation chloride cotransporters in retinal neurons allow opposite responses to GABA.

Authors:  N Vardi; L L Zhang; J A Payne; P Sterling
Journal:  J Neurosci       Date:  2000-10-15       Impact factor: 6.167

5.  Sometimes you see them, sometimes you don't: IPSCs in the rat superficial superior colliculus.

Authors:  Michelle D Edwards; Bettina Platt
Journal:  Exp Brain Res       Date:  2003-01-31       Impact factor: 1.972

6.  Hyperpolarizing inhibition develops without trophic support by GABA in cultured rat midbrain neurons.

Authors:  Stefan Titz; Michael Hans; Wolfgang Kelsch; Andrea Lewen; Dieter Swandulla; Ulrich Misgeld
Journal:  J Physiol       Date:  2003-08-01       Impact factor: 5.182

7.  Expression of the voltage-gated chloride channel ClC-2 in rod bipolar cells of the rat retina.

Authors:  R Enz; B J Ross; G R Cutting
Journal:  J Neurosci       Date:  1999-11-15       Impact factor: 6.167

8.  What is the functional role of the thalidomide binding protein cereblon?

Authors:  Xiu-Bao Chang; A Keith Stewart
Journal:  Int J Biochem Mol Biol       Date:  2011-09-10

9.  Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons.

Authors:  W Kelsch; S Hormuzdi; E Straube; A Lewen; H Monyer; U Misgeld
Journal:  J Neurosci       Date:  2001-11-01       Impact factor: 6.167

Review 10.  Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.

Authors:  Joseph Glykys; Volodymyr Dzhala; Kiyoshi Egawa; Kristopher T Kahle; Eric Delpire; Kevin Staley
Journal:  Trends Neurosci       Date:  2017-04-18       Impact factor: 13.837
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