Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Aziridinomitosanes via lactam cyclization.

Literature DB >> 20738104

Aziridinomitosanes via lactam cyclization.

Abstract

Aziridinomitosane ketones 4 and 24 are accessed by internal acyl anion equivalent-lactam cyclization of 29 in a convergent route. The key aziridinolactam 6 is prepared by tin-lithium exchange via the lithiated aziridine 11.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2010 PMID： 20738104 PMCID： PMC2946824 DOI： 10.1021/ol101595u

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

14 in total

1. DNA Cross-Linking Agents as Antitumor Drugs.

Authors: Scott R. Rajski; Robert M. Williams
Journal: Chem Rev Date: 1998-12-17 Impact factor: 60.622

Review 2. Mechanisms of in situ activation for DNA-targeting antitumor agents.

Authors: Scott E Wolkenberg; Dale L Boger
Journal: Chem Rev Date: 2002-07 Impact factor: 60.622

3. Utilization of the intact carbamoyl group of L-(NH2CO-13C,15N) citrulline in mitomycin biosynthesis by Streptomyces verticillatus.

Authors: U Hornemann; J H Eggert
Journal: J Antibiot (Tokyo) Date: 1975-10 Impact factor: 2.649

4. Total Synthesis of (-)- and (+)-Balanol(1).

Authors: John W. Lampe; Philip F. Hughes; Christopher K. Biggers; Shelley H. Smith; Hong Hu
Journal: J Org Chem Date: 1996-07-12 Impact factor: 4.354

5. Precursors in the biosynthesis of FR-900482, a novel antitumor antibiotic produced by Streptomyces sandaensis.

Authors: T Fujita; S Takase; T Otsuka; H Terano; M Kohsaka
Journal: J Antibiot (Tokyo) Date: 1988-03 Impact factor: 2.649

6. D-glucosamine and L-citrulline, precursors in mitomycin biosynthesis by Streptomyces verticillatus.

Authors: Y Hornemann; J P Kehrer; C S Nunez; R L Ranieri
Journal: J Am Chem Soc Date: 1974-01-09 Impact factor: 15.419

7. To enzyme analogues by lock and key chemistry with crown compounds. Part 1. Enantiomeric differentiation by configurationally chiral cryptands synthesised from L-tartaric acid and D-mannitol.

Authors: W D Curtis; D A Laidler; J F Stoddart; G H Jones
Journal: J Chem Soc Perkin 1 Date: 1977-08

3. Synthesis of cis-C-iodo-N-tosyl-aziridines using diiodomethyllithium: reaction optimization, product scope and stability, and a protocol for selection of stationary phase for chromatography.

Authors: Tom Boultwood; Dominic P Affron; Aaron D Trowbridge; James A Bull
Journal: J Org Chem Date: 2013-06-18 Impact factor: 4.354

3 in total

Aziridinomitosanes via lactam cyclization.

1. DNA Cross-Linking Agents as Antitumor Drugs.

Review 2. Mechanisms of in situ activation for DNA-targeting antitumor agents.

3. Utilization of the intact carbamoyl group of L-(NH2CO-13C,15N) citrulline in mitomycin biosynthesis by Streptomyces verticillatus.

4. Total Synthesis of (-)- and (+)-Balanol(1).

5. Precursors in the biosynthesis of FR-900482, a novel antitumor antibiotic produced by Streptomyces sandaensis.

6. D-glucosamine and L-citrulline, precursors in mitomycin biosynthesis by Streptomyces verticillatus.

7. To enzyme analogues by lock and key chemistry with crown compounds. Part 1. Enantiomeric differentiation by configurationally chiral cryptands synthesised from L-tartaric acid and D-mannitol.

8. Simple, efficient catalyst system for the palladium-catalyzed amination of aryl chlorides, bromides, and triflates.

9. A general and efficient copper catalyst for the amidation of aryl halides.

10. Synthesis of 7-Epi +-FR900482: an epimer of comparable anti-cancer activity.

1. Acetone promoted 1,4-migration of an alkoxycarbonyl group on a syn-1,2-diamine.

2. Crystal structure of tert-butyl 4-[4-(4-fluoro-phen-yl)-2-methyl-but-3-yn-2-yl]piperazine-1-carboxyl-ate.

3. Synthesis of cis-C-iodo-N-tosyl-aziridines using diiodomethyllithium: reaction optimization, product scope and stability, and a protocol for selection of stationary phase for chromatography.