Literature DB >> 20721309

Synthesis of 1-(Substituted Phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as Potential Anti-inflammatory Agents.

Madhavi Gangapuram1, Kinfe K Redda.   

Abstract

Fifteen novel 1-(substituted phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydro- pyridine-5-carboxylic acid diethylamide (7, 15) were synthesized in fair to good yields via sodium borohydride reduction of the corresponding 1-(substituted phenylcarbonyl/ sulfonylimino)-3-diethylcarbamoyl pyridinium ylides (6, 14) in absolute ethanol.

Entities:  

Year:  2006        PMID： 20721309      PMCID： PMC2922769          DOI： 10.1002/jhet.5570430327

Source DB:  PubMed          Journal:  J Heterocycl Chem        ISSN： 0022-152X            Impact factor:   2.193


  13 in total

1.  A diastereoselective synthesis of 2,4-disubstituted piperidines: scaffolds for drug discovery.

Authors:  P S Watson; B Jiang; B Scott
Journal:  Org Lett       Date:  2000-11-16       Impact factor: 6.005

2.  Synthesis and pharmacological evaluations of N-(substituted benzoylamino)-5-carbethoxymethyl-1,2,3,6-tetrahydropyridines as potential antiinflammatory agents.

Authors:  K Yoon; T Wilson; S Williams; K Redda
Journal:  Drugs Exp Clin Res       Date:  2000

3.  Synthesis and anti-inflammatory activities of N-benzoylamino-1,2,3,6-tetrahydropyridine analogs.

Authors:  B Mochona; T Wilson; K Redda
Journal:  Drugs Exp Clin Res       Date:  2003

Review 4.  The chemistry and pharmacology of tetrahydropyridines.

Authors:  N N Mateeva; L L Winfield; K K Redda
Journal:  Curr Med Chem       Date:  2005       Impact factor: 4.530

5.  Trail of ironies to Parkinson's disease.

Authors:  R Lewin
Journal:  Science       Date:  1984-06-08       Impact factor: 47.728

6.  Syntheses of N-substituted 2(3,4)-pyridylcarboxylic acid hydrazides with analgesic and antiinflammatory activity.

Authors:  K Redda; L A Corleto; E E Knaus
Journal:  J Med Chem       Date:  1979-09       Impact factor: 7.446

7.  Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.

Authors:  R E Heikkila; A Hess; R C Duvoisin
Journal:  Science       Date:  1984-06-29       Impact factor: 47.728

8.  Synthesis of N-[[(substituted-phenyl)carbonyl]amino]-1,2,3,6-tetrahydropyridines with analgesic and hyperglycemic activity.

Authors:  J M Yeung; L A Corleto; E E Knaus
Journal:  J Med Chem       Date:  1982-06       Impact factor: 7.446

9.  Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Authors:  W Gessner; A Brossi; R Shen; C W Abell
Journal:  J Med Chem       Date:  1985-03       Impact factor: 7.446

10.  Synthesis and toxicity toward nigrostriatal dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analogues.

Authors:  D S Fries; J de Vries; B Hazelhoff; A S Horn
Journal:  J Med Chem       Date:  1986-03       Impact factor: 7.446
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  4 in total

1.  Synthesis of Substituted N-[4(5-Methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-yl]benzamide/benzene Sulfonamides as Anti-Inflammatory and Anti-Cancer Agents.

Authors:  Madhavi Gangapuram; Kinfe K Redda
Journal:  J Heterocycl Chem       Date:  2009-05-01       Impact factor: 2.193

2.  Synthesis of 2-(N-Benzylpyrrolyl)-benzimidazoles Using Polyphosphoric Acid Prompted Cyclocondensation.

Authors:  Bereket Mochona; Laine Le; Madhavi Gangapuram; Nelly Mateeva; Tiffany Ardley; Kinfe K Redda
Journal:  J Heterocycl Chem       Date:  2010-11-01       Impact factor: 2.193

3.  Synthesis and biological evaluation of substituted N-[3-(1H-pyrrol-1-yl)methyl]-1,2,5,6-tetrahydropyridin-1-yl]benzamide/benzene sulfonamides as anti-inflammatory agents.

Authors:  Madhavi Gangapuram; Elizabeth Mazzio; Suresh Eyunni; Karam F A Soliman; Kinfe K Redda
Journal:  Arch Pharm (Weinheim)       Date:  2014-03-02       Impact factor: 3.751

4.  Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity.

Authors:  Suvankar Das; Cristiane J da Silva; Marina de M Silva; Maria Dayanne de A Dantas; Ângelo de Fátima; Ana Lúcia T Góis Ruiz; Cleiton M da Silva; João Ernesto de Carvalho; Josué C C Santos; Isis M Figueiredo; Edeildo F da Silva-Júnior; Thiago M de Aquino; João X de Araújo-Júnior; Goutam Brahmachari; Luzia Valentina Modolo
Journal:  J Adv Res       Date:  2017-10-31       Impact factor: 10.479
  4 in total

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