Literature DB >> 11073674

A diastereoselective synthesis of 2,4-disubstituted piperidines: scaffolds for drug discovery.

P S Watson1, B Jiang, B Scott.   

Abstract

A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete control of reaction selectivity merely by changing the order of the reaction sequence. These targets provide convenient platforms for drug discovery which contain easily modified points of diversity.

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Year:  2000        PMID： 11073674     DOI： 10.1021/ol006589o

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  29 in total

1.  Metallaphotoredox-Catalyzed Cross-Electrophile Csp3-Csp3 Coupling of Aliphatic Bromides.

Authors:  Russell T Smith; Xiaheng Zhang; Juan A Rincón; Javier Agejas; Carlos Mateos; Mario Barberis; Susana García-Cerrada; Oscar de Frutos; David W C MacMillan
Journal:  J Am Chem Soc       Date:  2018-12-10       Impact factor: 15.419

2.  Organometallic enantiomeric scaffolding: a strategy for the enantiocontrolled construction of regio- and stereodivergent trisubstituted piperidines from a common precursor.

Authors:  Heilam Wong; Ethel C Garnier-Amblard; Lanny S Liebeskind
Journal:  J Am Chem Soc       Date:  2011-04-22       Impact factor: 15.419

3.  Synthesis of 1-(Substituted Phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as Potential Anti-inflammatory Agents.

Authors:  Madhavi Gangapuram; Kinfe K Redda
Journal:  J Heterocycl Chem       Date:  2006-05-01       Impact factor: 2.193

4.  Stereocontrolled synthesis of vicinally functionalized piperidines by nucleophilic β-addition of alkyllithiums to α-aryl substituted piperidine enecarbamates.

Authors:  Timothy K Beng; Hironori Takeuchi; Manuel Weber; Richmond Sarpong
Journal:  Chem Commun (Camb)       Date:  2015-05-04       Impact factor: 6.222

5.  Enantioselective approach to quinolizidines: total synthesis of cermizine D and formal syntheses of senepodine G and cermizine C.

Authors:  Nagarathanam Veerasamy; Erik C Carlson; Nathan D Collett; Mrinmoy Saha; Rich G Carter
Journal:  J Org Chem       Date:  2013-04-29       Impact factor: 4.354

6.  Application of the aza-Achmatowicz oxidative rearrangement for the stereoselective synthesis of the Cassia and Prosopis alkaloid family.

Authors:  Carolyn A Leverett; Michael P Cassidy; Albert Padwa
Journal:  J Org Chem       Date:  2006-10-27       Impact factor: 4.354

7.  Stereoselective synthesis of the eastern quinolizidine portion of himeradine A.

Authors:  Nathan D Collett; Rich G Carter
Journal:  Org Lett       Date:  2011-07-12       Impact factor: 6.005

8.  Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues.

Authors:  Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Peter A Crooks
Journal:  J Org Chem       Date:  2009-08-21       Impact factor: 4.354

9.  2,10-Dihydr-oxy-13-methyl-13-aza-tetra-cyclo-[9.3.1.0.0]penta-deca-3(8),4,6-triene-9,15-dione.

Authors:  J Suresh; U C Nithya; R Suresh Kumar; S Perumal; P L Nilantha Lakshman
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-05-07

10.  Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis.

Authors:  Neil Brown; Baohan Xie; Nataliya Markina; David Vandervelde; Jean-Pierre H Perchellet; Elisabeth M Perchellet; Kyle R Crow; Keith R Buszek
Journal:  Bioorg Med Chem Lett       Date:  2008-07-24       Impact factor: 2.823
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