Literature DB >> 20526413

Synthesis of Substituted N-[4(5-Methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-yl]benzamide/benzene Sulfonamides as Anti-Inflammatory and Anti-Cancer Agents.

Madhavi Gangapuram1, Kinfe K Redda.   

Abstract

Fourteen novel substituted N-[4(5-methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-y1] benzamide/benzene sulfonamides (11a-n) were synthesized in fair to good yields via sodium borohydride reduction of the corresponding substituted N-(benzoylimino)-4-(5-methyl/5-phenyl-1,3,4-oxadiazol-2yl) pyridinium ylide (10a-n) in absolute ethanol.

Entities:  

Year:  2009        PMID： 20526413      PMCID： PMC2880475          DOI： 10.1002/jhet.62

Source DB:  PubMed          Journal:  J Heterocycl Chem        ISSN： 0022-152X            Impact factor:   2.193


  17 in total

1.  Synthesis and anti-inflammatory activities of N-benzoylamino-1,2,3,6-tetrahydropyridine analogs.

Authors:  B Mochona; T Wilson; K Redda
Journal:  Drugs Exp Clin Res       Date:  2003

2.  Synthesis of 1-(Substituted Phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as Potential Anti-inflammatory Agents.

Authors:  Madhavi Gangapuram; Kinfe K Redda
Journal:  J Heterocycl Chem       Date:  2006-05-01       Impact factor: 2.193

Review 3.  The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease.

Authors:  J C Breitner
Journal:  Annu Rev Med       Date:  1996       Impact factor: 13.739

Review 4.  Mechanism of action of antiinflammatory drugs.

Authors:  J R Vane; R M Botting
Journal:  Int J Tissue React       Date:  1998

5.  Evaluation of blood-brain barrier passage of a muscarine M1 agonist and a series of analogous tetrahydropyridines measured by in vivo microdialysis.

Authors:  H H Sveigaard; L Dalgaard
Journal:  Pharm Res       Date:  2000-01       Impact factor: 4.200

6.  Synthesis and antibacterial studies of a new series of 1,2-bis(1,3, 4-oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2, 4-triazol-3-yl)ethanes.

Authors:  B S Holla; R Gonsalves; S Shenoy
Journal:  Eur J Med Chem       Date:  2000-02       Impact factor: 6.514

7.  Syntheses of N-substituted 2(3,4)-pyridylcarboxylic acid hydrazides with analgesic and antiinflammatory activity.

Authors:  K Redda; L A Corleto; E E Knaus
Journal:  J Med Chem       Date:  1979-09       Impact factor: 7.446

8.  Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study.

Authors:  K Andersen; L J Launer; A Ott; A W Hoes; M M Breteler; A Hofman
Journal:  Neurology       Date:  1995-08       Impact factor: 9.910

9.  Synthesis of N-(carbonylamino)-1,2,3,6-tetrahydropyridines with analgesic, antiinflammatory, and hyperglycemic activity.

Authors:  J M Yeung; L A Corleto; E E Knaus
Journal:  J Med Chem       Date:  1982-02       Impact factor: 7.446

10.  2-amino-5-substituted 1,3,4-oxadiazoles and 5-imino-2-substituted delta-2-1,3,4-oxadiazolines. A group of novel muscle relaxants.

Authors:  H L Yale; K Losee
Journal:  J Med Chem       Date:  1966-07       Impact factor: 7.446
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  5 in total

1.  Gold-catalyzed nitrene transfer to activated alkynes: formation of α,β-unsaturated amidines.

Authors:  Chaoqun Li; Liming Zhang
Journal:  Org Lett       Date:  2011-02-25       Impact factor: 6.005

2.  Synthesis of 2-(N-Benzylpyrrolyl)-benzimidazoles Using Polyphosphoric Acid Prompted Cyclocondensation.

Authors:  Bereket Mochona; Laine Le; Madhavi Gangapuram; Nelly Mateeva; Tiffany Ardley; Kinfe K Redda
Journal:  J Heterocycl Chem       Date:  2010-11-01       Impact factor: 2.193

3.  Synthesis and biological evaluation of substituted N-[3-(1H-pyrrol-1-yl)methyl]-1,2,5,6-tetrahydropyridin-1-yl]benzamide/benzene sulfonamides as anti-inflammatory agents.

Authors:  Madhavi Gangapuram; Elizabeth Mazzio; Suresh Eyunni; Karam F A Soliman; Kinfe K Redda
Journal:  Arch Pharm (Weinheim)       Date:  2014-03-02       Impact factor: 3.751

4.  Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.

Authors:  Jing Li; Justin S Cisar; Cong-Ying Zhou; Brunilda Vera; Howard Williams; Abimael D Rodríguez; Benjamin F Cravatt; Daniel Romo
Journal:  Nat Chem       Date:  2013-05-19       Impact factor: 24.427

5.  Design, Synthesis and Evaluation of Novel N-Substituted-[Benzoylamino]-5-Ethyl-1,2,3,6-Tetrahydropyridines as Potential Anti-Cancer Agents.

Authors:  Elizabeth D Henderson; Madhavi Gangapuram; Suresh Kumar Vk Eyunni; Kinfe K Redda; Tiffany Wilson-Ardley
Journal:  Madridge J Pharm Res       Date:  2019-03-04
  5 in total

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