| Literature DB >> 20719877 |
Joan Steitz1, Sumit Borah, Demian Cazalla, Victor Fok, Robin Lytle, Rachel Mitton-Fry, Kasandra Riley, Tasleem Samji.
Abstract
Like their host cells, many viruses produce noncoding (nc)RNAs. These show diversity with respect to time of expression during viral infection, length and structure, protein-binding partners and relative abundance compared with their host-cell counterparts. Viruses, with their limited genomic capacity, presumably evolve or acquire ncRNAs only if they selectively enhance the viral life cycle or assist the virus in combating the host's response to infection. Despite much effort, identifying the functions of viral ncRNAs has been extremely challenging. Recent technical advances and enhanced understanding of host-cell ncRNAs promise accelerated insights into the RNA warfare mounted by this fascinating class of RNPs.Entities:
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Year: 2011 PMID: 20719877 PMCID: PMC3039937 DOI: 10.1101/cshperspect.a005165
Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN: 1943-0264 Impact factor: 10.005