Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Is metabolic syndrome a mild form of Cushing's syndrome?

Literature DB >> 20711679

Is metabolic syndrome a mild form of Cushing's syndrome?

Abstract

The Metabolic Syndrome is a diagnosis of increasing prevalence that is noted to share multiple clinical features with Cushing's syndrome. Several studies suggest abnormalities in the Hypothalamic-Pituitary-Adrenal axis to be associated with this disease and tissue-specific hypercortisolemia is being investigated as a possible contributing factor. More research is needed to explore the relation between cortisol and the metabolic syndrome which, if confirmed, will have major therapeutic and public health implications.

Entities: Disease

Mesh：

Substances：

Year: 2010 PMID： 20711679 DOI： 10.1007/s11154-010-9142-4

Source DB: PubMed Journal: Rev Endocr Metab Disord ISSN： 1389-9155 Impact factor: 6.514

59 in total

Review 1. The prevalence of metabolic syndrome in various populations.

Authors: Genovefa D Kolovou; Katherine K Anagnostopoulou; Klelia D Salpea; Dimitri P Mikhailidis
Journal: Am J Med Sci Date: 2007-06 Impact factor: 2.378

Review 2. INCB-13739, an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for the treatment of type 2 diabetes.

Authors: Atul Tiwari
Journal: IDrugs Date: 2010-04

3. 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients.

Authors: Raoul Desbriere; Vincent Vuaroqueaux; Vincent Achard; Sandrine Boullu-Ciocca; Martin Labuhn; Anne Dutour; Michel Grino
Journal: Obesity (Silver Spring) Date: 2006-05 Impact factor: 5.002

Review 4. 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation.

Authors: Mark S Cooper; Paul M Stewart
Journal: J Clin Endocrinol Metab Date: 2009-10-16 Impact factor: 5.958

5. Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients.

Authors: René Baudrand; Cristian A Carvajal; Arnoldo Riquelme; Mauricio Morales; Nancy Solis; Margarita Pizarro; Alex Escalona; Camilo Boza; Gustavo Pérez; Angélica Domínguez; Marco Arrese; Carlos E Fardella
Journal: Obes Surg Date: 2009-08-19 Impact factor: 4.129

6. Hyperactivity of the hypothalamo-pituitary-adrenal axis in obesity: a study of ACTH, AVP, beta-lipotrophin and cortisol responses to insulin-induced hypoglycaemia.

Authors: J U Weaver; P G Kopelman; L McLoughlin; M L Forsling; A Grossman
Journal: Clin Endocrinol (Oxf) Date: 1993-09 Impact factor: 3.478

7. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.

Authors: K G Alberti; P Z Zimmet
Journal: Diabet Med Date: 1998-07 Impact factor: 4.359

8. Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss.

Authors: Stefan Engeli; Jana Böhnke; Mareike Feldpausch; Kerstin Gorzelniak; Ute Heintze; Jürgen Janke; Friedrich C Luft; Arya M Sharma
Journal: Obes Res Date: 2004-01

9. Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene.

Authors: Yasumasa Iwasaki; Shinobu Takayasu; Mitsuru Nishiyama; Makoto Tsugita; Takafumi Taguchi; Masato Asai; Masanori Yoshida; Machiko Kambayashi; Kozo Hashimoto
Journal: Mol Cell Endocrinol Date: 2008-02-02 Impact factor: 4.102

10. Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.

Authors: Zoi Michailidou; Anthony P Coll; Christopher J Kenyon; Nicholas M Morton; Stephen O'Rahilly; Jonathan R Seckl; Karen E Chapman
Journal: J Endocrinol Date: 2007-07 Impact factor: 4.286

8 in total

1. The impact of maternal overnutrition and obesity on hypothalamic-pituitary-adrenal axis response of offspring to stress.

Authors: N M Long; P W Nathanielsz; S P Ford
Journal: Domest Anim Endocrinol Date: 2012-01-11 Impact factor: 2.290

2. Effects of 11β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis.

Authors: J J Winnick; C J Ramnanan; V Saraswathi; J Roop; M Scott; P Jacobson; P Jung; R Basu; A D Cherrington; D S Edgerton
Journal: Am J Physiol Endocrinol Metab Date: 2013-02-12 Impact factor: 4.310

3. Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency.

Authors: Kevin C J Yuen; Charles T Roberts; Jan Frystyk; William D Rooney; James R Pollaro; Bethany J Klopfenstein; Jonathan Q Purnell
Journal: J Clin Endocrinol Metab Date: 2014-07-11 Impact factor: 5.958

Review 4. Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?

Authors: Mark D DeBoer; Aldo A M Lima; Reinaldo B Oría; Rebecca J Scharf; Sean R Moore; Max A Luna; Richard L Guerrant
Journal: Nutr Rev Date: 2012-11 Impact factor: 7.110