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Literature DB >> 20709095

Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways.

Timothy M Brown¹, Annette E Allen, Jonathan Wynne, David L Paul, Hugh D Piggins, Robert J Lucas.

Abstract

Emerging evidence indicates rods can communicate with retinal ganglion cells (RGCs) via pathways that do not involve gap-junctions. Here we investigated the significance of such pathways for central visual responses, using mice lacking a key gap junction protein (Cx36(-/-)) and carrying a mutation that disrupts cone phototransduction (Gnat2(cpfl3)). Electrophysiological recordings spanning the lateral geniculate revealed rod-mediated ON and OFF visual responses in virtually every cell from all major anatomical sub-compartments of this nucleus. Hence, we demonstrate that one or more classes of RGC receive input from Cx36-independent rod pathways and drive extensive ON and OFF responses across the visual thalamus.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Connexins

Year: 2010 PMID： 20709095 PMCID： PMC3741614 DOI： 10.1016/j.visres.2010.08.010

Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886

36 in total

1. An alternative pathway for rod signals in the rodent retina: rod photoreceptors, cone bipolar cells, and the localization of glutamate receptors.

Authors: I Hack; L Peichl; J H Brandstätter
Journal: Proc Natl Acad Sci U S A Date: 1999-11-23 Impact factor: 11.205

2. In search of the visual pigment template.

Authors: V I Govardovskii; N Fyhrquist; T Reuter; D G Kuzmin; K Donner
Journal: Vis Neurosci Date: 2000 Jul-Aug Impact factor: 3.241

3. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit.

Authors: P D Calvert; N V Krasnoperova; A L Lyubarsky; T Isayama; M Nicoló; B Kosaras; G Wong; K S Gannon; R F Margolskee; R L Sidman; E N Pugh; C L Makino; J Lem
Journal: Proc Natl Acad Sci U S A Date: 2000-12-05 Impact factor: 11.205

4. Second sight? Ecker JL, Dumitrescu ON, Wong KY, Alam NM, Chen SK, LeGates T, Renna JM, Prusky GT, Berson DM, Hattar S (2010) Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 67:49-60.

Authors: David Hicks
Journal: Graefes Arch Clin Exp Ophthalmol Date: 2011-02-19 Impact factor: 3.117

Review 5. Rod pathways: the importance of seeing nothing.

Authors: L T Sharpe; A Stockman
Journal: Trends Neurosci Date: 1999-11 Impact factor: 13.837

6. Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.

Authors: Ji-Jie Pang; Fan Gao; Janis Lem; Debra E Bramblett; David L Paul; Samuel M Wu
Journal: Proc Natl Acad Sci U S A Date: 2009-12-14 Impact factor: 11.205

7. Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

Authors: Gurprit S Lall; Victoria L Revell; Hiroshi Momiji; Jazi Al Enezi; Cara M Altimus; Ali D Güler; Carlos Aguilar; Morven A Cameron; Susan Allender; Mark W Hankins; Robert J Lucas
Journal: Neuron Date: 2010-05-13 Impact factor: 17.173

Review 8. Melanopsin and inner retinal photoreception.

Authors: Helena J Bailes; Robert J Lucas
Journal: Cell Mol Life Sci Date: 2009-10-29 Impact factor: 9.261

9. Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.

Authors: Muhammad M Abd-El-Barr; Mark E Pennesi; Shannon M Saszik; Andrew J Barrow; Janis Lem; Debra E Bramblett; David L Paul; Laura J Frishman; Samuel M Wu
Journal: J Neurophysiol Date: 2009-07-08 Impact factor: 2.714

10. Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms.

Authors: Didem Göz; Keith Studholme; Douglas A Lappi; Mark D Rollag; Ignacio Provencio; Lawrence P Morin
Journal: PLoS One Date: 2008-09-05 Impact factor: 3.240

16 in total

10. The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions.

Authors: Timothy M Brown; Annette E Allen; Jazi al-Enezi; Jonathan Wynne; Luc Schlangen; Vanja Hommes; Robert J Lucas
Journal: PLoS One Date: 2013-01-03 Impact factor: 3.240

Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways.

1. An alternative pathway for rod signals in the rodent retina: rod photoreceptors, cone bipolar cells, and the localization of glutamate receptors.

2. In search of the visual pigment template.

3. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit.

4. Second sight? Ecker JL, Dumitrescu ON, Wong KY, Alam NM, Chen SK, LeGates T, Renna JM, Prusky GT, Berson DM, Hattar S (2010) Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 67:49-60.

Review 5. Rod pathways: the importance of seeing nothing.

6. Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.

7. Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

Review 8. Melanopsin and inner retinal photoreception.

9. Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.

10. Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms.

1. Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes.

Review 2. Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.

3. Rod Photoreceptors Signal Fast Changes in Daylight Levels Using a Cx36-Independent Retinal Pathway in Mouse.

4. Rod Photoresponse Kinetics Limit Temporal Contrast Sensitivity in Mesopic Vision.

5. Multiple hypothalamic cell populations encoding distinct visual information.

6. Visual responses in mice lacking critical components of all known retinal phototransduction cascades.

7. Intrinsic and extrinsic cues regulate the daily profile of mouse lateral habenula neuronal activity.

8. Melanopsin-based brightness discrimination in mice and humans.

9. Mouse ganglion-cell photoreceptors are driven by the most sensitive rod pathway and by both types of cones.

10. The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions.