OBJECTIVES: To address the fact that a decrease in the relative renal uptake of 99mTc-mercaptoacetyltriglycine (MAG3) on serial MAG3 scans may indicate a loss of function and require a change in management by providing guidance as to what constitutes a meaningful change in serial relative function measurements as well determining the normal variation of other common MAG3 renogram parameters. METHODS: A prospective study was conducted in 24 male urology patients with stable renal function. The mean age was 66.5 ± 7.9 (SD) years; the mean serum creatinine was 1.38 ± 0.57 (SD) mg/dL, and the MAG3 renal scans were performed a mean of 11 ± 8 days apart. Each MAG3 scan included a measurement of relative function as well as the time to maximum counts and 20 minutes to maximum count ratios for both cortical and whole kidney regions of interest. RESULTS: The Pearson and intraclass correlations for the baseline and repeat measurements of relative renal function were both 0.98. Bland-Altman plots showed no bias between the baseline and repeat relative uptake measurements. The mean difference between 2 repeated measurements of the relative MAG3 uptake was 0.04 ± 2.88% (SD) for the left kidney and 0.08 ± 3.07% (SD) for the right kidney. Comparable results were obtained for the other renogram parameters. CONCLUSIONS: Measurements of relative renal uptake of MAG3 and common renogram parameters are highly reproducible; a decrease in relative uptake ≥7% (ie, 50%-43%) implies a loss in renal function.
OBJECTIVES: To address the fact that a decrease in the relative renal uptake of 99mTc-mercaptoacetyltriglycine (MAG3) on serial MAG3 scans may indicate a loss of function and require a change in management by providing guidance as to what constitutes a meaningful change in serial relative function measurements as well determining the normal variation of other common MAG3 renogram parameters. METHODS: A prospective study was conducted in 24 male urology patients with stable renal function. The mean age was 66.5 ± 7.9 (SD) years; the mean serum creatinine was 1.38 ± 0.57 (SD) mg/dL, and the MAG3 renal scans were performed a mean of 11 ± 8 days apart. Each MAG3 scan included a measurement of relative function as well as the time to maximum counts and 20 minutes to maximum count ratios for both cortical and whole kidney regions of interest. RESULTS: The Pearson and intraclass correlations for the baseline and repeat measurements of relative renal function were both 0.98. Bland-Altman plots showed no bias between the baseline and repeat relative uptake measurements. The mean difference between 2 repeated measurements of the relative MAG3 uptake was 0.04 ± 2.88% (SD) for the left kidney and 0.08 ± 3.07% (SD) for the right kidney. Comparable results were obtained for the other renogram parameters. CONCLUSIONS: Measurements of relative renal uptake of MAG3 and common renogram parameters are highly reproducible; a decrease in relative uptake ≥7% (ie, 50%-43%) implies a loss in renal function.
Authors: I Gordon; P Colarinha; J Fettich; S Fischer; J Frökier; K Hahn; L Kabasakal; M Mitjavila; P Olivier; A Piepsz; U Porn; R Sixt; J van Velzen Journal: Eur J Nucl Med Date: 2001-03
Authors: A Prigent; P Cosgriff; G F Gates; G Granerus; E J Fine; K Itoh; M Peters; A Piepsz; M Rehling; M Rutland; A Taylor Journal: Semin Nucl Med Date: 1999-04 Impact factor: 4.446
Authors: Fabio P Esteves; Andrew Taylor; Amita Manatunga; Russell D Folks; Meghna Krishnan; Ernest V Garcia Journal: AJR Am J Roentgenol Date: 2006-12 Impact factor: 3.959
Authors: A Taylor; J Nally; M Aurell; D Blaufox; M Dondi; E Dubovsky; E Fine; E Fommei; G Geyskes; G Granerus; D Kahn; K Morton; H Y Oei; C Russell; G Sfakianakis; J Fletcher Journal: J Nucl Med Date: 1996-11 Impact factor: 10.057
Authors: Zhi-Yang Low; Siân E Allen; Vimoshan Arumuham; Laura May Davis; Clare Allen; Jamshed Bomanji; R Daron Smith Journal: Cent European J Urol Date: 2021-02-06