Literature DB >> 20708149

A centrosome kinase modulates antitumor drug sensitivity.

Jeffrey L Salisbury1.   

Abstract

In this issue of Cancer Cell, Ahmed and coworkers identify SIK2 as a centrosome kinase and show that it controls the localization of the centriole linker protein C-Nap1. Interference with SIK2 function results in loss of normal mitotic spindle function and increased sensitivity to antitumor drugs. 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20708149      PMCID： PMC2932443          DOI： 10.1016/j.ccr.2010.07.008

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  8 in total

1.  Centrosomes as command centres for cellular control.

Authors:  S J Doxsey
Journal:  Nat Cell Biol       Date:  2001-05       Impact factor: 28.824

Review 2.  The coordination of centrosome reproduction with nuclear events during the cell cycle.

Authors:  G Sluder; E H Hinchcliffe
Journal:  Curr Top Dev Biol       Date:  2000       Impact factor: 4.897

3.  Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest.

Authors:  Keith Mikule; Benedicte Delaval; Philipp Kaldis; Agata Jurcyzk; Polla Hergert; Stephen Doxsey
Journal:  Nat Cell Biol       Date:  2007-02       Impact factor: 28.824

Review 4.  Mechanisms of malignant progression.

Authors:  Robert A Weinberg
Journal:  Carcinogenesis       Date:  2008-05-02       Impact factor: 4.944

5.  SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.

Authors:  Ahmed Ashour Ahmed; Zhen Lu; Nicholas B Jennings; Dariush Etemadmoghadam; Luisa Capalbo; Rodrigo O Jacamo; Nuno Barbosa-Morais; Xiao-Feng Le; Pablo Vivas-Mejia; Gabriel Lopez-Berestein; Geoffrey Grandjean; Geoffrey Bartholomeusz; Warren Liao; Michael Andreeff; David Bowtell; David M Glover; Anil K Sood; Robert C Bast
Journal:  Cancer Cell       Date:  2010-08-09       Impact factor: 31.743

Review 6.  Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Authors:  Juan-Manuel Schvartzman; Rocio Sotillo; Robert Benezra
Journal:  Nat Rev Cancer       Date:  2010-02       Impact factor: 60.716

7.  Rootletin forms centriole-associated filaments and functions in centrosome cohesion.

Authors:  Susanne Bahe; York-Dieter Stierhof; Christopher J Wilkinson; Florian Leiss; Erich A Nigg
Journal:  J Cell Biol       Date:  2005-10-03       Impact factor: 10.539

8.  C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.

Authors:  A M Fry; T Mayor; P Meraldi; Y D Stierhof; K Tanaka; E A Nigg
Journal:  J Cell Biol       Date:  1998-06-29       Impact factor: 10.539
  8 in total

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