Literature DB >> 20708153

SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.

Ahmed Ashour Ahmed1, Zhen Lu, Nicholas B Jennings, Dariush Etemadmoghadam, Luisa Capalbo, Rodrigo O Jacamo, Nuno Barbosa-Morais, Xiao-Feng Le, Pablo Vivas-Mejia, Gabriel Lopez-Berestein, Geoffrey Grandjean, Geoffrey Bartholomeusz, Warren Liao, Michael Andreeff, David Bowtell, David M Glover, Anil K Sood, Robert C Bast.   

Abstract

Regulators of mitosis have been successfully targeted to enhance response to taxane chemotherapy. Here, we show that the salt inducible kinase 2 (SIK2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, C-Nap1, through S2392 phosphorylation. Interference with the known SIK2 inhibitor PKA induced SIK2-dependent centrosome splitting in interphase while SIK2 depletion blocked centrosome separation in mitosis, sensitizing ovarian cancers to paclitaxel in culture and in xenografts. Depletion of SIK2 also delayed G1/S transition and reduced AKT phosphorylation. Higher expression of SIK2 significantly correlated with poor survival in patients with high-grade serous ovarian cancers. We believe these data identify SIK2 as a plausible target for therapy in ovarian cancers. 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20708153      PMCID： PMC3954541          DOI： 10.1016/j.ccr.2010.06.018

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  32 in total

1.  Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.

Authors:  T U Mayer; T M Kapoor; S J Haggarty; R W King; S L Schreiber; T J Mitchison
Journal:  Science       Date:  1999-10-29       Impact factor: 47.728

2.  Requirement of a centrosomal activity for cell cycle progression through G1 into S phase.

Authors:  E H Hinchcliffe; F J Miller; M Cham; A Khodjakov; G Sluder
Journal:  Science       Date:  2001-02-23       Impact factor: 47.728

3.  Dissociating the centrosomal matrix protein AKAP450 from centrioles impairs centriole duplication and cell cycle progression.

Authors:  Guy Keryer; Oliwia Witczak; Annie Delouvée; Wolfram A Kemmner; Danielle Rouillard; Kjetil Tasken; Michel Bornens
Journal:  Mol Biol Cell       Date:  2003-03-07       Impact factor: 4.138

4.  Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis.

Authors:  Yoshiko Katoh; Hiroshi Takemori; Nanao Horike; Junko Doi; Masaaki Muraoka; Li Min; Mitsuhiro Okamoto
Journal:  Mol Cell Endocrinol       Date:  2004-03-31       Impact factor: 4.102

5.  Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

Authors:  Hsiao-Chun Huang; Jue Shi; James D Orth; Timothy J Mitchison
Journal:  Cancer Cell       Date:  2009-10-06       Impact factor: 31.743

6.  The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles.

Authors:  Thibault Mayor; Ulrike Hacker; York-Dieter Stierhof; Erich A Nigg
Journal:  J Cell Sci       Date:  2002-08-15       Impact factor: 5.285

7.  CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis.

Authors:  C R Carlson; O Witczak; L Vossebein; J C Labbé; B S Skålhegg; G Keryer; F W Herberg; P Collas; K Taskén
Journal:  J Cell Sci       Date:  2001-09       Impact factor: 5.285

8.  Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis.

Authors:  H B Landsverk; C R Carlson; R L Steen; L Vossebein; F W Herberg; K Taskén; P Collas
Journal:  J Cell Sci       Date:  2001-09       Impact factor: 5.285

9.  Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression.

Authors:  A Khodjakov; C L Rieder
Journal:  J Cell Biol       Date:  2001-04-02       Impact factor: 10.539

10.  Centrosome cohesion is regulated by a balance of kinase and phosphatase activities.

Authors:  P Meraldi; E A Nigg
Journal:  J Cell Sci       Date:  2001-10       Impact factor: 5.285
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  65 in total

1.  Erythropoietin Stimulates Tumor Growth via EphB4.

Authors:  Sunila Pradeep; Jie Huang; Edna M Mora; Alpa M Nick; Min Soon Cho; Sherry Y Wu; Kyunghee Noh; Chad V Pecot; Rajesha Rupaimoole; Martin A Stein; Stephan Brock; Yunfei Wen; Chiyi Xiong; Kshipra Gharpure; Jean M Hansen; Archana S Nagaraja; Rebecca A Previs; Pablo Vivas-Mejia; Hee Dong Han; Wei Hu; Lingegowda S Mangala; Behrouz Zand; Loren J Stagg; John E Ladbury; Bulent Ozpolat; S Neslihan Alpay; Masato Nishimura; Rebecca L Stone; Koji Matsuo; Guillermo N Armaiz-Peña; Heather J Dalton; Christopher Danes; Blake Goodman; Cristian Rodriguez-Aguayo; Carola Kruger; Armin Schneider; Shyon Haghpeykar; Padmavathi Jaladurgam; Mien-Chie Hung; Robert L Coleman; Jinsong Liu; Chun Li; Diana Urbauer; Gabriel Lopez-Berestein; David B Jackson; Anil K Sood
Journal:  Cancer Cell       Date:  2015-10-17       Impact factor: 31.743

2.  Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.

Authors:  Fu-Chia Yang; Ya-Huei Lin; Wei-Hao Chen; Jing-Yi Huang; Hsin-Yun Chang; Su-Hui Su; Hsiao-Ting Wang; Chun-Yi Chiang; Pang-Hung Hsu; Ming-Daw Tsai; Bertrand Chin-Ming Tan; Sheng-Chung Lee
Journal:  J Biol Chem       Date:  2013-10-15       Impact factor: 5.157

Review 3.  Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.

Authors:  Marc N Wein; Marc Foretz; David E Fisher; Ramnik J Xavier; Henry M Kronenberg
Journal:  Trends Endocrinol Metab       Date:  2018-08-24       Impact factor: 12.015

4.  NRG1/ERBB3 Pathway Activation Induces Acquired Resistance to XPO1 Inhibitors.

Authors:  Takahito M Miyake; Sunila Pradeep; Emine Bayraktar; Elaine Stur; Katelyn F Handley; Sherry Y Wu; Cristian Rodriguez-Aguayo; Ju-Seog Lee; Gabriel Lopez-Berestein; Robert L Coleman; Anil K Sood
Journal:  Mol Cancer Ther       Date:  2020-06-04       Impact factor: 6.261

5.  Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.

Authors:  Chia-Wei Lee; Fu-Chia Yang; Hsin-Yun Chang; Hanyi Chou; Bertrand Chin-Ming Tan; Sheng-Chung Lee
Journal:  J Biol Chem       Date:  2014-07-25       Impact factor: 5.157

6.  Hematogenous metastasis of ovarian cancer: rethinking mode of spread.

Authors:  Sunila Pradeep; Seung W Kim; Sherry Y Wu; Masato Nishimura; Pradeep Chaluvally-Raghavan; Takahito Miyake; Chad V Pecot; Sun-Jin Kim; Hyun Jin Choi; Farideh Z Bischoff; Julie Ann Mayer; Li Huang; Alpa M Nick; Carolyn S Hall; Cristian Rodriguez-Aguayo; Behrouz Zand; Heather J Dalton; Thiruvengadam Arumugam; Ho Jeong Lee; Hee Dong Han; Min Soon Cho; Rajesha Rupaimoole; Lingegowda S Mangala; Vasudha Sehgal; Sang Cheul Oh; Jinsong Liu; Ju-Seog Lee; Robert L Coleman; Prahlad Ram; Gabriel Lopez-Berestein; Isaiah J Fidler; Anil K Sood
Journal:  Cancer Cell       Date:  2014-07-14       Impact factor: 31.743

7.  Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.

Authors:  Jun-Ichi Sakamaki; Accalia Fu; Courtney Reeks; Stephen Baird; Chantal Depatie; Mufida Al Azzabi; Nabeel Bardeesy; Anne-Claude Gingras; Siu-Pok Yee; Robert A Screaton
Journal:  Nat Cell Biol       Date:  2014-03       Impact factor: 28.824

8.  2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.

Authors:  Sherry Y Wu; Xianbin Yang; Kshipra M Gharpure; Hiroto Hatakeyama; Martin Egli; Michael H McGuire; Archana S Nagaraja; Takahito M Miyake; Rajesha Rupaimoole; Chad V Pecot; Morgan Taylor; Sunila Pradeep; Malgorzata Sierant; Cristian Rodriguez-Aguayo; Hyun J Choi; Rebecca A Previs; Guillermo N Armaiz-Pena; Li Huang; Carlos Martinez; Tom Hassell; Cristina Ivan; Vasudha Sehgal; Richa Singhania; Hee-Dong Han; Chang Su; Ji Hoon Kim; Heather J Dalton; Chandra Kovvali; Khandan Keyomarsi; Nigel A J McMillan; Willem W Overwijk; Jinsong Liu; Ju-Seog Lee; Keith A Baggerly; Gabriel Lopez-Berestein; Prahlad T Ram; Barbara Nawrot; Anil K Sood
Journal:  Nat Commun       Date:  2014-03-12       Impact factor: 14.919

9.  Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy.

Authors:  Fu-Chia Yang; Bertrand Chin-Ming Tan; Wei-Hao Chen; Ya-Huei Lin; Jing-Yi Huang; Hsin-Yun Chang; Hui-Yu Sun; Pang-Hung Hsu; Gunn-Guang Liou; James Shen; Ching-Jin Chang; Chau-Chung Han; Ming-Daw Tsai; Sheng-Chung Lee
Journal:  J Biol Chem       Date:  2013-01-15       Impact factor: 5.157

10.  SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival.

Authors:  Kimberly E Maxfield; Jennifer Macion; Hariprasad Vankayalapati; Angelique W Whitehurst
Journal:  Mol Cell Biol       Date:  2016-11-28       Impact factor: 4.272
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